The effect of acute administration of chlorothiazide upon the pressor responsiveness to angiotensin and norepinephrine

Jack G. Silah; Robert E Jones; F. A. Bashour; Norman M Kaplan

doi:10.1016/0002-8703(65)90269-3

The effect of acute administration of chlorothiazide upon the pressor responsiveness to angiotensin and norepinephrine

Jack G. Silah, Robert E Jones, F. A. Bashour, Norman M Kaplan

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The effects of the acute intravenous administration of chlorothiazide upon the pressor responsiveness to norepinephrine and angiotensin II in normal human subjects have been examined by measuring blood pressure and digital blood flow. Chlorothiazide did blunt the pressor responsiveness to norepinephrine, but not to angiotensin, when they were administered in the same infusion. Chlorothiazide did not decrease pressor responsiveness to either agent when they were administered simultaneously but in separate infusions. The effect of chlorothiazide upon the pressor response to norepinephrine when the two are admixed is presumably related to instability of norepinephrine in the alkaline pH of the chlorothiazide solution.

Original language	English (US)
Pages (from-to)	301-305
Number of pages	5
Journal	American heart journal
Volume	69
Issue number	3
DOIs	https://doi.org/10.1016/0002-8703(65)90269-3
State	Published - Mar 1965

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/0002-8703(65)90269-3

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title = "The effect of acute administration of chlorothiazide upon the pressor responsiveness to angiotensin and norepinephrine",

abstract = "The effects of the acute intravenous administration of chlorothiazide upon the pressor responsiveness to norepinephrine and angiotensin II in normal human subjects have been examined by measuring blood pressure and digital blood flow. Chlorothiazide did blunt the pressor responsiveness to norepinephrine, but not to angiotensin, when they were administered in the same infusion. Chlorothiazide did not decrease pressor responsiveness to either agent when they were administered simultaneously but in separate infusions. The effect of chlorothiazide upon the pressor response to norepinephrine when the two are admixed is presumably related to instability of norepinephrine in the alkaline pH of the chlorothiazide solution.",

author = "Silah, {Jack G.} and Jones, {Robert E} and Bashour, {F. A.} and Kaplan, {Norman M}",

note = "Funding Information: From the Department This work was supported Health Service. Received for publication May 18. 1964. *Research Fellow in Med;cine. **Medical student. *Associate Professor of Internal Medicine. ****Assistant Professor of Internal Medicine. Hines Blvd.. Dallas, Tex., 75325. tchlorothiazide (Diuril) was kindly supplied $Norepinephrine was I-norepinephrine bitartrate $Angiotensin was synthetic valine-S-angiotensin Pharmaceuticals. Summit, N.J.",

year = "1965",

month = mar,

doi = "10.1016/0002-8703(65)90269-3",

language = "English (US)",

volume = "69",

pages = "301--305",

journal = "American heart journal",

issn = "0002-8703",

publisher = "Mosby Inc.",

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T1 - The effect of acute administration of chlorothiazide upon the pressor responsiveness to angiotensin and norepinephrine

AU - Silah, Jack G.

AU - Jones, Robert E

AU - Bashour, F. A.

AU - Kaplan, Norman M

N1 - Funding Information: From the Department This work was supported Health Service. Received for publication May 18. 1964. *Research Fellow in Med;cine. **Medical student. *Associate Professor of Internal Medicine. ****Assistant Professor of Internal Medicine. Hines Blvd.. Dallas, Tex., 75325. tchlorothiazide (Diuril) was kindly supplied $Norepinephrine was I-norepinephrine bitartrate $Angiotensin was synthetic valine-S-angiotensin Pharmaceuticals. Summit, N.J.

PY - 1965/3

Y1 - 1965/3

N2 - The effects of the acute intravenous administration of chlorothiazide upon the pressor responsiveness to norepinephrine and angiotensin II in normal human subjects have been examined by measuring blood pressure and digital blood flow. Chlorothiazide did blunt the pressor responsiveness to norepinephrine, but not to angiotensin, when they were administered in the same infusion. Chlorothiazide did not decrease pressor responsiveness to either agent when they were administered simultaneously but in separate infusions. The effect of chlorothiazide upon the pressor response to norepinephrine when the two are admixed is presumably related to instability of norepinephrine in the alkaline pH of the chlorothiazide solution.

AB - The effects of the acute intravenous administration of chlorothiazide upon the pressor responsiveness to norepinephrine and angiotensin II in normal human subjects have been examined by measuring blood pressure and digital blood flow. Chlorothiazide did blunt the pressor responsiveness to norepinephrine, but not to angiotensin, when they were administered in the same infusion. Chlorothiazide did not decrease pressor responsiveness to either agent when they were administered simultaneously but in separate infusions. The effect of chlorothiazide upon the pressor response to norepinephrine when the two are admixed is presumably related to instability of norepinephrine in the alkaline pH of the chlorothiazide solution.

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JO - American heart journal

JF - American heart journal

IS - 3

ER -

The effect of acute administration of chlorothiazide upon the pressor responsiveness to angiotensin and norepinephrine

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