The effect of androgenic hormones on the reduced nicotinamide adenine dinucleotide phosphate: Δ4 3 ketosteroid 5α oxidoreductase of rat ventral prostate

R. J. Moore, J. D. Wilson

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

The regulation of the 5α reductase that converts testosterone to dihydrotestosterone in rat ventral prostate was investigated by studying the effect of the administration of androgens to castrate animals for varying periods of time. Testerosterone propionate treatment resulted in a 7 fold increase above the normal level in the total activity of the enzyme per prostate and caused a similar increase in the specific activity of the enzyme both in homogenate and in the nucleus. Thyroid, adrenal, pituitary, and estrogenic hormones do not appear to play a major role in the mediation of this androgenic control. On the basis of time sequence studies following testosterone propionate administration and of studies comparing the effects of different steroids on prostate growth and enzyme content, it is concluded that the enzyme activity correlates with the growth response of the prostate to androgen treatment.

Original languageEnglish (US)
Pages (from-to)581-592
Number of pages12
JournalEndocrinology
Volume93
Issue number3
StatePublished - 1973

Fingerprint

Ketosteroids
NADP
Prostate
Oxidoreductases
Hormones
Enzymes
Androgens
Testosterone Propionate
Pituitary Hormones
Dihydrotestosterone
Propionates
Growth
Testosterone
Thyroid Gland
Steroids

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

The effect of androgenic hormones on the reduced nicotinamide adenine dinucleotide phosphate : Δ4 3 ketosteroid 5α oxidoreductase of rat ventral prostate. / Moore, R. J.; Wilson, J. D.

In: Endocrinology, Vol. 93, No. 3, 1973, p. 581-592.

Research output: Contribution to journalArticle

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