TY - JOUR
T1 - The effect of Eleutheroside E on behavioral alterations in murine sleep deprivation stress model
AU - Huang, Lin Zhang
AU - Wei, Lei
AU - Zhao, Hong Fang
AU - Huang, Bao Kang
AU - Rahman, Khalid
AU - Qin, Lu Ping
PY - 2011/5/11
Y1 - 2011/5/11
N2 - Eleutheroside E (EE), a principal component of Eleutherococcus senticosus, has been reported to have anti-inflammatory and protective effects in ischemia heart etc. However, whether it can mitigate behavioral alterations induced by sleep deprivation, has not yet been elucidated. Numerous studies have demonstrated that memory deficits induced by sleep deprivation in experimental animals can be used as a model of behavioral alterations. The present study investigated the effect of EE, on cognitive performances and biochemical parameters of sleep-deprived mice. Animals were repeatedly treated with saline, 10 or 50 mg/kg EE and sleep-deprived for 72 h by the multiple platform method. Briefly, groups of 5-6 mice were placed in water tanks (45 x 34 x 17 cm), containing 12 platforms (3 cm in diameter) each, surrounded by water up to 1 cm beneath the surface or kept in their home cage. After sleep deprivation, mice showed significant behavioral impairment as evident by reduced latency entering into a dark chamber, locomotion and correctly rate in Y maze, and increased monoamines in hippocampus. However, repeated treatment with EE restored these behavioral and biochemical alterations in mice. In conclusion, the beneficial effect of EE may provide an effective and powerful strategy to alleviate behavioral alterations induced by sleep deprivation.
AB - Eleutheroside E (EE), a principal component of Eleutherococcus senticosus, has been reported to have anti-inflammatory and protective effects in ischemia heart etc. However, whether it can mitigate behavioral alterations induced by sleep deprivation, has not yet been elucidated. Numerous studies have demonstrated that memory deficits induced by sleep deprivation in experimental animals can be used as a model of behavioral alterations. The present study investigated the effect of EE, on cognitive performances and biochemical parameters of sleep-deprived mice. Animals were repeatedly treated with saline, 10 or 50 mg/kg EE and sleep-deprived for 72 h by the multiple platform method. Briefly, groups of 5-6 mice were placed in water tanks (45 x 34 x 17 cm), containing 12 platforms (3 cm in diameter) each, surrounded by water up to 1 cm beneath the surface or kept in their home cage. After sleep deprivation, mice showed significant behavioral impairment as evident by reduced latency entering into a dark chamber, locomotion and correctly rate in Y maze, and increased monoamines in hippocampus. However, repeated treatment with EE restored these behavioral and biochemical alterations in mice. In conclusion, the beneficial effect of EE may provide an effective and powerful strategy to alleviate behavioral alterations induced by sleep deprivation.
KW - Behavioral alteration
KW - Eleutheroside E
KW - Locomotor
KW - Passive avoidance
KW - Y maze
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UR - http://www.scopus.com/inward/citedby.url?scp=79953775902&partnerID=8YFLogxK
U2 - 10.1016/j.ejphar.2011.02.036
DO - 10.1016/j.ejphar.2011.02.036
M3 - Article
C2 - 21376030
AN - SCOPUS:79953775902
SN - 0014-2999
VL - 658
SP - 150
EP - 155
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 2-3
ER -