To further define the metabolism of CsA, we studied the biotransformation of the drug in male and female rats using high-pressure liquid chromatographic (HPLC) analysis of CsA and primary CsA metabolites in whole blood. Moreover, we characterized the metabolism of Csa following administration of a known hepatic mixed function oxidase inducer, phenobarbital, and a commonly used, clinically relevant immunosuppressive agent, methylprednisolone.
|Original language||English (US)|
|Number of pages||4|
|Issue number||2 SUPPL. 2|
|Publication status||Published - 1988|
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