The effect of phenobarbital and methylprednisolone on the biotransformation of cyclosporine in the rat

K. L. Brayman, J. Nakamura, A. Naji, C. F. Barker, M. A. Choti, L. M. Shaw

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Abstract

To further define the metabolism of CsA, we studied the biotransformation of the drug in male and female rats using high-pressure liquid chromatographic (HPLC) analysis of CsA and primary CsA metabolites in whole blood. Moreover, we characterized the metabolism of Csa following administration of a known hepatic mixed function oxidase inducer, phenobarbital, and a commonly used, clinically relevant immunosuppressive agent, methylprednisolone.

Original languageEnglish (US)
Pages (from-to)553-556
Number of pages4
JournalTransplantation Proceedings
Volume20
Issue number2 SUPPL. 2
Publication statusPublished - 1988

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ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Brayman, K. L., Nakamura, J., Naji, A., Barker, C. F., Choti, M. A., & Shaw, L. M. (1988). The effect of phenobarbital and methylprednisolone on the biotransformation of cyclosporine in the rat. Transplantation Proceedings, 20(2 SUPPL. 2), 553-556.