The effect of phenobarbital and methylprednisolone on the biotransformation of cyclosporine in the rat

K. L. Brayman, J. Nakamura, A. Naji, C. F. Barker, M. A. Choti, L. M. Shaw

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

To further define the metabolism of CsA, we studied the biotransformation of the drug in male and female rats using high-pressure liquid chromatographic (HPLC) analysis of CsA and primary CsA metabolites in whole blood. Moreover, we characterized the metabolism of Csa following administration of a known hepatic mixed function oxidase inducer, phenobarbital, and a commonly used, clinically relevant immunosuppressive agent, methylprednisolone.

Original languageEnglish (US)
Pages (from-to)553-556
Number of pages4
JournalTransplantation Proceedings
Volume20
Issue number2 SUPPL. 2
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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    Brayman, K. L., Nakamura, J., Naji, A., Barker, C. F., Choti, M. A., & Shaw, L. M. (1988). The effect of phenobarbital and methylprednisolone on the biotransformation of cyclosporine in the rat. Transplantation Proceedings, 20(2 SUPPL. 2), 553-556.