The effect of respiratory alkalosis on oxygen consumption in anesthetized patients

Roger M. Slater, Tommy Symreng, Sam T. Sum Ping, James Starr, David Tatman

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Study Objective: To investigate whether hyperventilation significantly altered oxygen consumption in anesthetized and paralyzed patients undergoing surgery. Design: Open crossover trial with 1 hour of hyperventilation preceded and followed by 1 hour of normoventilation. Setting: University medical center. Patients: Eight patients (five men and three women) undergoing lengthy orthopedic surgery with general anesthesia and muscle paralysis. Interventions: After baseline normoventilationfor 1 hour (Period 1), the anesthetized patients were hyperventilated to an arterial carbon dioxide tension (PaCO2) of 20 to 25 mmHg for 1 hour (Period 2). Patients then experienced another hour of normoventilation (Period 5). Measurements and Main Results: Hemodynamic variables, electrocardiography, temperature, end-tidal partial pressure of CO2 (PETCO2), oxygen consumption (VO2), carbon dioxide production, and minute ventilation were continuously followed throughout the study, and arterial blood gases were drawn at the beginning and end of each study period. During the period of hyperventilation, pH was significantly higher and P.ETCO2 and (PaCO2) significantly lower compared with the periods of normoventilation. (VO2), was significantly increased during hyperventilation compared with the periods of normoventilation. Hemodynamic variables and temperature were similar in the three study periods. Conclusions: In anesthetized paralyzed patients, there is an increase in whole-body (VO2), with hypocapnic alkalosis.

Original languageEnglish (US)
Pages (from-to)462-467
Number of pages6
JournalJournal of Clinical Anesthesia
Volume4
Issue number6
DOIs
StatePublished - 1992

Fingerprint

Respiratory Alkalosis
Oxygen Consumption
Hyperventilation
Carbon Dioxide
Hemodynamics
Alkalosis
Temperature
Partial Pressure
Paralysis
Cross-Over Studies
General Anesthesia
Orthopedics
Ventilation
Electrocardiography
Gases
Muscles

Keywords

  • Alkalosis, respiratory
  • anesthesia, general
  • neuromuscular blocking drugs
  • oxygen, consumption of
  • vecuronium

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

The effect of respiratory alkalosis on oxygen consumption in anesthetized patients. / Slater, Roger M.; Symreng, Tommy; Sum Ping, Sam T.; Starr, James; Tatman, David.

In: Journal of Clinical Anesthesia, Vol. 4, No. 6, 1992, p. 462-467.

Research output: Contribution to journalArticle

Slater, Roger M. ; Symreng, Tommy ; Sum Ping, Sam T. ; Starr, James ; Tatman, David. / The effect of respiratory alkalosis on oxygen consumption in anesthetized patients. In: Journal of Clinical Anesthesia. 1992 ; Vol. 4, No. 6. pp. 462-467.
@article{dabf4b2590ff45009b79828fff4f81ed,
title = "The effect of respiratory alkalosis on oxygen consumption in anesthetized patients",
abstract = "Study Objective: To investigate whether hyperventilation significantly altered oxygen consumption in anesthetized and paralyzed patients undergoing surgery. Design: Open crossover trial with 1 hour of hyperventilation preceded and followed by 1 hour of normoventilation. Setting: University medical center. Patients: Eight patients (five men and three women) undergoing lengthy orthopedic surgery with general anesthesia and muscle paralysis. Interventions: After baseline normoventilationfor 1 hour (Period 1), the anesthetized patients were hyperventilated to an arterial carbon dioxide tension (PaCO2) of 20 to 25 mmHg for 1 hour (Period 2). Patients then experienced another hour of normoventilation (Period 5). Measurements and Main Results: Hemodynamic variables, electrocardiography, temperature, end-tidal partial pressure of CO2 (PETCO2), oxygen consumption (VO2), carbon dioxide production, and minute ventilation were continuously followed throughout the study, and arterial blood gases were drawn at the beginning and end of each study period. During the period of hyperventilation, pH was significantly higher and P.ETCO2 and (PaCO2) significantly lower compared with the periods of normoventilation. (VO2), was significantly increased during hyperventilation compared with the periods of normoventilation. Hemodynamic variables and temperature were similar in the three study periods. Conclusions: In anesthetized paralyzed patients, there is an increase in whole-body (VO2), with hypocapnic alkalosis.",
keywords = "Alkalosis, respiratory, anesthesia, general, neuromuscular blocking drugs, oxygen, consumption of, vecuronium",
author = "Slater, {Roger M.} and Tommy Symreng and {Sum Ping}, {Sam T.} and James Starr and David Tatman",
year = "1992",
doi = "10.1016/0952-8180(92)90219-Q",
language = "English (US)",
volume = "4",
pages = "462--467",
journal = "Journal of Clinical Anesthesia",
issn = "0952-8180",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - The effect of respiratory alkalosis on oxygen consumption in anesthetized patients

AU - Slater, Roger M.

AU - Symreng, Tommy

AU - Sum Ping, Sam T.

AU - Starr, James

AU - Tatman, David

PY - 1992

Y1 - 1992

N2 - Study Objective: To investigate whether hyperventilation significantly altered oxygen consumption in anesthetized and paralyzed patients undergoing surgery. Design: Open crossover trial with 1 hour of hyperventilation preceded and followed by 1 hour of normoventilation. Setting: University medical center. Patients: Eight patients (five men and three women) undergoing lengthy orthopedic surgery with general anesthesia and muscle paralysis. Interventions: After baseline normoventilationfor 1 hour (Period 1), the anesthetized patients were hyperventilated to an arterial carbon dioxide tension (PaCO2) of 20 to 25 mmHg for 1 hour (Period 2). Patients then experienced another hour of normoventilation (Period 5). Measurements and Main Results: Hemodynamic variables, electrocardiography, temperature, end-tidal partial pressure of CO2 (PETCO2), oxygen consumption (VO2), carbon dioxide production, and minute ventilation were continuously followed throughout the study, and arterial blood gases were drawn at the beginning and end of each study period. During the period of hyperventilation, pH was significantly higher and P.ETCO2 and (PaCO2) significantly lower compared with the periods of normoventilation. (VO2), was significantly increased during hyperventilation compared with the periods of normoventilation. Hemodynamic variables and temperature were similar in the three study periods. Conclusions: In anesthetized paralyzed patients, there is an increase in whole-body (VO2), with hypocapnic alkalosis.

AB - Study Objective: To investigate whether hyperventilation significantly altered oxygen consumption in anesthetized and paralyzed patients undergoing surgery. Design: Open crossover trial with 1 hour of hyperventilation preceded and followed by 1 hour of normoventilation. Setting: University medical center. Patients: Eight patients (five men and three women) undergoing lengthy orthopedic surgery with general anesthesia and muscle paralysis. Interventions: After baseline normoventilationfor 1 hour (Period 1), the anesthetized patients were hyperventilated to an arterial carbon dioxide tension (PaCO2) of 20 to 25 mmHg for 1 hour (Period 2). Patients then experienced another hour of normoventilation (Period 5). Measurements and Main Results: Hemodynamic variables, electrocardiography, temperature, end-tidal partial pressure of CO2 (PETCO2), oxygen consumption (VO2), carbon dioxide production, and minute ventilation were continuously followed throughout the study, and arterial blood gases were drawn at the beginning and end of each study period. During the period of hyperventilation, pH was significantly higher and P.ETCO2 and (PaCO2) significantly lower compared with the periods of normoventilation. (VO2), was significantly increased during hyperventilation compared with the periods of normoventilation. Hemodynamic variables and temperature were similar in the three study periods. Conclusions: In anesthetized paralyzed patients, there is an increase in whole-body (VO2), with hypocapnic alkalosis.

KW - Alkalosis, respiratory

KW - anesthesia, general

KW - neuromuscular blocking drugs

KW - oxygen, consumption of

KW - vecuronium

UR - http://www.scopus.com/inward/record.url?scp=0027077754&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027077754&partnerID=8YFLogxK

U2 - 10.1016/0952-8180(92)90219-Q

DO - 10.1016/0952-8180(92)90219-Q

M3 - Article

C2 - 1457113

AN - SCOPUS:0027077754

VL - 4

SP - 462

EP - 467

JO - Journal of Clinical Anesthesia

JF - Journal of Clinical Anesthesia

SN - 0952-8180

IS - 6

ER -