The effect of somatostatin on the response of GLI to the intraduodenal administration of glucose, protein, and fat

H. Sakurai, R. E. Dobbs, Roger H Unger

Research output: Contribution to journalArticle

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Abstract

The effects of somatostatin on GLI release during the absorption of intraduodenally administered glucose, casein hydrolysate and longchain triglycerides were studied in conscious dogs. Whereas, after an intraduodenal glucose load, GLI rose promptly in saline-infused control experiments to a peak of 5 ng/ml (SEM ± 4) in 60 minutes, significantly lower values were observed during somatostatin infusion (P<0.025 - 0.05). A similar reduction in the magnitude of the GLI response to intraduodenally administered casein hydrolysate (P<0.05) and fat (p<0.05) was observed.

Original languageEnglish (US)
Pages (from-to)427-430
Number of pages4
JournalDiabetologia
Volume11
Issue number5
DOIs
StatePublished - Oct 1 1975

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Keywords

  • Glucagon-like immunoreactivity (GLI)
  • fat
  • glucagon
  • glucose
  • insulin
  • protein meal
  • somatostatin
  • triglyceride

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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