The emerging role of speckle-type POZ protein (SPOP) in cancer development

Ram Shankar Mani

doi:10.1016/j.drudis.2014.07.009

The emerging role of speckle-type POZ protein (SPOP) in cancer development

Ram Shankar Mani

Research output: Contribution to journal › Review article › peer-review

74 Scopus citations

Abstract

Speckle-type POZ (pox virus and zinc finger protein) protein (SPOP) is an E3 ubiquitin ligase adaptor protein that is frequently mutated in prostate and endometrial cancers. All the cancer-associated SPOP mutations reported to date are clustered in the meprin and TRAF (Tumor necrosis factor receptor-associated factor) homology (MATH) domain, presumably affecting substrate binding. SPOP mutations in prostate cancer are mutually exclusive with the ETS (Erythroblast transformation-specific) family gene rearrangements and define a distinct molecular subclass of prostate cancer. SPOP mutations contribute to prostate cancer development by altering the steady-state levels of key components in the androgen-signaling pathway.

Original language	English (US)
Pages (from-to)	1498-1502
Number of pages	5
Journal	Drug Discovery Today
Volume	19
Issue number	9
DOIs	https://doi.org/10.1016/j.drudis.2014.07.009
State	Published - Sep 2014

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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10.1016/j.drudis.2014.07.009

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title = "The emerging role of speckle-type POZ protein (SPOP) in cancer development",

abstract = "Speckle-type POZ (pox virus and zinc finger protein) protein (SPOP) is an E3 ubiquitin ligase adaptor protein that is frequently mutated in prostate and endometrial cancers. All the cancer-associated SPOP mutations reported to date are clustered in the meprin and TRAF (Tumor necrosis factor receptor-associated factor) homology (MATH) domain, presumably affecting substrate binding. SPOP mutations in prostate cancer are mutually exclusive with the ETS (Erythroblast transformation-specific) family gene rearrangements and define a distinct molecular subclass of prostate cancer. SPOP mutations contribute to prostate cancer development by altering the steady-state levels of key components in the androgen-signaling pathway.",

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AB - Speckle-type POZ (pox virus and zinc finger protein) protein (SPOP) is an E3 ubiquitin ligase adaptor protein that is frequently mutated in prostate and endometrial cancers. All the cancer-associated SPOP mutations reported to date are clustered in the meprin and TRAF (Tumor necrosis factor receptor-associated factor) homology (MATH) domain, presumably affecting substrate binding. SPOP mutations in prostate cancer are mutually exclusive with the ETS (Erythroblast transformation-specific) family gene rearrangements and define a distinct molecular subclass of prostate cancer. SPOP mutations contribute to prostate cancer development by altering the steady-state levels of key components in the androgen-signaling pathway.

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The emerging role of speckle-type POZ protein (SPOP) in cancer development

Abstract

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