The epidemiology of EGFR mutations

Hisayuki Shigematsu, Adi Gazdar

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The discovery of mutations in the tyrosine kinase (TK) domain of the EGFR in lung cancers has generated enormous interest since they appear to be associated with sensitivity to EGFR-tyrosine kinase inhibitors (TKIs). These mutations appear to occur predominantly in highly select patient populations: East Asian ethnicity, female gender, never-smoker status and adenocarcinoma subtype. While the mutational status of EGFR appears to be of considerable importance in determining response to EGFR-TKIs in lung cancer, it is not the sole factor. Accurate prediction of therapeutic response to EGFR-TKIs is likely to require a complete understanding of the erbB gene family members and their role in cancer pathogenesis and progression. Further molecular-based studies are required to analyse the biological functions of different EGFR-TK mutations and to assess their effect on sensitivity to EGFR-TKIs. Epidemiological studies may identify other possible factor(s) associated with the incidence of EGFR-TK mutations or with response to EGFR-TKIs.

Original languageEnglish (US)
Pages (from-to)4-8
Number of pages5
JournalSignal
Volume6
Issue number1
StatePublished - May 2005

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Protein-Tyrosine Kinases
Epidemiology
Mutation
erbB Genes
Lung Neoplasms
Epidemiologic Studies
Adenocarcinoma
Incidence
Population
Neoplasms

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)
  • Drug Discovery

Cite this

Shigematsu, H., & Gazdar, A. (2005). The epidemiology of EGFR mutations. Signal, 6(1), 4-8.

The epidemiology of EGFR mutations. / Shigematsu, Hisayuki; Gazdar, Adi.

In: Signal, Vol. 6, No. 1, 05.2005, p. 4-8.

Research output: Contribution to journalArticle

Shigematsu, H & Gazdar, A 2005, 'The epidemiology of EGFR mutations', Signal, vol. 6, no. 1, pp. 4-8.
Shigematsu H, Gazdar A. The epidemiology of EGFR mutations. Signal. 2005 May;6(1):4-8.
Shigematsu, Hisayuki ; Gazdar, Adi. / The epidemiology of EGFR mutations. In: Signal. 2005 ; Vol. 6, No. 1. pp. 4-8.
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