The evolution and genetics of innate immunity

Deborah A. Kimbrell, Bruce Beutler

Research output: Contribution to journalArticle

427 Citations (Scopus)

Abstract

The immune system provides protection from a wide range of pathogens. One component of immunity, the phylogenetically ancient innate immune response, fights infections from the moment of first contact and is the fundamental defensive weapon of multicellular organisms. The Toll family of receptors has a crucial role in immune defence. Studies in fruitflies and in mammals reveal that the defensive strategies of invertebrates and vertebrates are highly conserved at the molecular level, which raises the exciting prospects of an increased understanding of innate immunity.

Original languageEnglish (US)
Pages (from-to)256-267
Number of pages12
JournalNature Reviews Genetics
Volume2
Issue number4
DOIs
StatePublished - Apr 2001

Fingerprint

Molecular Evolution
Innate Immunity
Weapons
Invertebrates
fruit flies
immune system
Vertebrates
Mammals
Immune System
Immunity
immunity
invertebrates
vertebrates
mammals
receptors
pathogens
organisms
Infection
infection
innate immunity

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Genetics
  • Genetics(clinical)

Cite this

The evolution and genetics of innate immunity. / Kimbrell, Deborah A.; Beutler, Bruce.

In: Nature Reviews Genetics, Vol. 2, No. 4, 04.2001, p. 256-267.

Research output: Contribution to journalArticle

Kimbrell, Deborah A. ; Beutler, Bruce. / The evolution and genetics of innate immunity. In: Nature Reviews Genetics. 2001 ; Vol. 2, No. 4. pp. 256-267.
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