The expanding problem of adipose depot remodeling and postnatal adipocyte progenitor recruitment

Chelsea Hepler, Rana K Gupta

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The rising incidence of obesity and associated metabolic diseases has increased the urgency in understanding all aspects of adipose tissue biology. This includes the function of adipocytes, how adipose tissue expands in obesity, and how expanded adipose tissues in adults can impact physiology. Here, we highlight the growing appreciation for the importance of . de novo adipocyte differentiation to adipose tissue expansion in adult humans and animals. We detail recent efforts to identify adipose precursor populations that contribute to the physiological postnatal recruitment of white, brown, and beige adipocytes in mice, and summarize new data that reveal the complexity of adipose tissue development . in vivo.

Original languageEnglish (US)
JournalMolecular and Cellular Endocrinology
DOIs
StateAccepted/In press - Jun 14 2016

Fingerprint

Adipocytes
Adipose Tissue
Tissue
Obesity
White Adipocytes
Brown Adipocytes
Tissue Expansion
Metabolic Diseases
Physiology
Animals
Incidence
Population

Keywords

  • Adipogenesis
  • Adipose precursors
  • Beige adipocytes
  • Brown adipocyte
  • Obesity
  • White adipocytes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology

Cite this

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