The expanding problem of adipose depot remodeling and postnatal adipocyte progenitor recruitment

Chelsea Hepler, Rana K Gupta

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

The rising incidence of obesity and associated metabolic diseases has increased the urgency in understanding all aspects of adipose tissue biology. This includes the function of adipocytes, how adipose tissue expands in obesity, and how expanded adipose tissues in adults can impact physiology. Here, we highlight the growing appreciation for the importance of de novo adipocyte differentiation to adipose tissue expansion in adult humans and animals. We detail recent efforts to identify adipose precursor populations that contribute to the physiological postnatal recruitment of white, brown, and beige adipocytes in mice, and summarize new data that reveal the complexity of adipose tissue development in vivo.

Original languageEnglish (US)
Pages (from-to)95-108
Number of pages14
JournalMolecular and Cellular Endocrinology
Volume445
DOIs
StatePublished - Apr 15 2017

Keywords

  • Adipogenesis
  • Adipose precursors
  • Beige adipocytes
  • Brown adipocyte
  • Obesity
  • White adipocytes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology

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