The ferroptosis inducer erastin promotes proliferation and differentiation in human peripheral blood mononuclear cells

Ding Wang, Nan Xie, Wanli Gao, Rui Kang, Daolin Tang

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Peripheral blood mononuclear cells (PBMCs) contain multipotent progenitor cell populations and possess the potential to differentiate into various types of immune cells under both physiological and pathological conditions. Ferroptosis is a type of oxidative stress-associated cell death that is mainly mediated by lipid peroxidation. However, the function of ferroptosis in cell differentiation remains unknown. Here, we showed that the ferroptosis inducer erastin did not cause cell death in human PBMCs. In contrast, erastin-induced lipid peroxidation promoted human PBMC proliferation and differentiation into B cells and natural killer cells through inhibition of bone morphogenetic protein family expression. These findings uncover a new immune modulation function of erastin in promoting PBMC proliferation and differentiation.

Original languageEnglish (US)
Pages (from-to)1689-1695
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume503
Issue number3
DOIs
StatePublished - Sep 10 2018
Externally publishedYes

Keywords

  • Erastin
  • Ferroptosis
  • Immunity
  • Lipid peroxidation
  • PBMCs

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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