The future of cardiovascular clinical research in North America and beyond - Addressing challenges and leveraging opportunities through unique academic and grassroots collaborations

Matthew T. Roe, Kenneth W. Mahaffey, Justin A. Ezekowitz, John H. Alexander, Shaun G. Goodman, Adrian Hernandez, Tracy Temple, Lisa Berdan, Robert M. Califf, Robert A. Harrington, Eric D. Peterson, Paul W. Armstrong

Research output: Contribution to journalReview articlepeer-review

Abstract

Recent developments have highlighted the challenges facing cardiovascular clinical research in global contemporary practice, particularly in North America, including shifting priorities for drug development targets, increasing regulatory requirements, and expensive operational approaches for conducting randomized clinical trials. Nonetheless, emerging trends such as the consolidation of practices and hospitals into integrated health systems, the integration of electronic health records from thousands of practices into large data repositories to support prospective research studies, and streamlined operational approaches such as registry-based trials and risk-based monitoring have created numerous opportunities to disrupt the clinical research paradigm. Within this context, academic research organizations around the globe, particularly a strengthened collaboration of 3 established academic research organizations in North America, are uniquely positioned to promote and develop grassroots collaborations across all types of clinical practices, to delineate successful solutions to obstacles that limit clinical research initiatives, and to guide the future of cardiovascular research in the global research environment.

Original languageEnglish (US)
Pages (from-to)743-750
Number of pages8
JournalAmerican heart journal
Volume169
Issue number6
DOIs
StatePublished - Jun 1 2015
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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