@inbook{09cb05a254cd4af48a9c9212cad3cc98,
title = "The good, the bad, and the ugly: From planarians to parasites",
abstract = "Platyhelminthes can perhaps rightly be described as a phylum of the good, the bad, and the ugly: remarkable free-living worms that colonize land, river, and sea, which are often rife with color and can display extraordinary regenerative ability; parasitic worms like schistosomes that cause devastating disease and suffering; and monstrous tapeworms that are the stuff of nightmares. In this chapter, we will explore how our research expanded beyond free-living planarians to their gruesome parasitic cousins. We start with Schistosoma mansoni, which is not a new model; however, approaching these parasites from a developmental perspective required a reinvention that may hold generalizable lessons to basic biologists interested in pivoting to disease models. We then turn to our (re)establishment of the rat tapeworm Hymenolepis diminuta, a once-favorite model that had been largely forgotten by the molecular biology revolution. Here we tell our stories in three, first-person narratives in order to convey personal views of our experiences. Welcome to the dark side.",
keywords = "Cestodes, Emerging models, Planarians, Schistosomes, Tapeworms, Trematodes",
author = "Tania Rozario and Collins, {James J.} and Newmark, {Phillip A.}",
note = "Funding Information: We would like to acknowledge the many researchers not mentioned in this chapter whose excellent work could not be discussed in detail. We recognize that our success would not be possible without their contributions. None of this work would have been possible without the generous and flexible support of the Howard Hughes Medical Institute, of which PAN is an investigator. We are grateful to Melanie Issigonis for invaluable feedback in the writing of this manuscript. The figures were prepared by Matt Stefely at the Morgridge Institute for Research. Sincere thanks goes out to many colleagues and lab members who contributed significantly to the development of these models; specifically, the schistosome work was greatly aided by Fred Lewis, David Williams, Harini Iyer, Marla Tharp, Ryan King, Bo Wang, and Bram Lambrus, and the tapeworm work by Dick Davis, Jianbin Wang, Jennifer McDonald, and Edward Quinn. Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",
year = "2022",
month = jan,
doi = "10.1016/bs.ctdb.2021.12.015",
language = "English (US)",
isbn = "9780128201541",
series = "Current Topics in Developmental Biology",
publisher = "Academic Press Inc.",
pages = "345--373",
editor = "Bob Goldstein and Mansi Srivastava",
booktitle = "Emerging Model Systems in Developmental Biology",
}