TY - JOUR
T1 - The hedgehog response network
T2 - Sensors, switches, and routers
AU - Lum, Lawrence
AU - Beachy, Philip A.
PY - 2004/6/18
Y1 - 2004/6/18
N2 - The Hedgehog (Hh) signaling pathway is intimately linked to cell growth and differentiation, with normal roles in embryonic pattern formation and adult tissue homeostasis and pathological roles in tumor initiation and growth. Recent advances in our understanding of Hh response have resulted from the identification of new pathway components and new mechanisms of action for old pathway components. The most striking new finding is that signal transmission from membrane to cytoplasm proceeds through recruitment, by the seven-transmembrane protein Smoothened, of an atypical kinesin, which routes pathway activation by interaction with other components of a complex that includes the latent zinc finger transcription factor, Ci.
AB - The Hedgehog (Hh) signaling pathway is intimately linked to cell growth and differentiation, with normal roles in embryonic pattern formation and adult tissue homeostasis and pathological roles in tumor initiation and growth. Recent advances in our understanding of Hh response have resulted from the identification of new pathway components and new mechanisms of action for old pathway components. The most striking new finding is that signal transmission from membrane to cytoplasm proceeds through recruitment, by the seven-transmembrane protein Smoothened, of an atypical kinesin, which routes pathway activation by interaction with other components of a complex that includes the latent zinc finger transcription factor, Ci.
UR - http://www.scopus.com/inward/record.url?scp=2942738996&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=2942738996&partnerID=8YFLogxK
U2 - 10.1126/science.1098020
DO - 10.1126/science.1098020
M3 - Review article
C2 - 15205520
AN - SCOPUS:2942738996
SN - 0036-8075
VL - 304
SP - 1755
EP - 1759
JO - Science
JF - Science
IS - 5678
ER -