The Hippo Pathway in Liver Homeostasis and Pathophysiology

Jordan H. Driskill, Duojia Pan

Research output: Contribution to journalReview articlepeer-review

Abstract

Studies of the regenerative capacity of the liver have converged on the Hippo pathway, a serine/threonine kinase cascade discovered in Drosophila and conserved from unicellular organisms to mammals. Genetic studies of mouse and rat livers have revealed that the Hippo pathway is a key regulator of liver size, regeneration, development, metabolism, and homeostasis and that perturbations in the Hippo pathway can lead to the development of common liver diseases, such as fatty liver disease and liver cancer. In turn, pharmacological targeting of the Hippo pathway may be utilized to boost regeneration and to prevent the development and progression of liver diseases. We review current insights provided by the Hippo pathway into liver pathophysiology. Furthermore, we present a path forward for future studies to understand how newly identified components of the Hippo pathway may control liver physiology and how the Hippo pathway is regulated in the liver.

Original languageEnglish (US)
Pages (from-to)299-322
Number of pages24
JournalAnnual Review of Pathology: Mechanisms of Disease
Volume16
DOIs
StatePublished - Jan 24 2021

Keywords

  • Fatty liver disease
  • Hippo pathway
  • Liver cancer
  • Metabolism
  • Regeneration
  • Yap/taz

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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