The hippo signaling pathway in development and cancer

Research output: Contribution to journalReview article

1195 Citations (Scopus)

Abstract

First discovered in Drosophila, the Hippo signaling pathway is a conserved regulator of organ size. Central to this pathway is a kinase cascade leading from the tumor suppressor Hippo (Mst1 and Mst2 in mammals) to the oncoprotein Yki (YAP and TAZ in mammals), a transcriptional coactivator of target genes involved in cell proliferation and survival. Here, I review recent progress in elucidating the molecular mechanism and physiological function of Hippo signaling in Drosophila and mammals. These studies suggest that the core Hippo kinase cascade integrates multiple upstream inputs, enabling dynamic regulation of tissue homeostasis in animal development and physiology.

Original languageEnglish (US)
Pages (from-to)491-505
Number of pages15
JournalDevelopmental Cell
Volume19
Issue number4
DOIs
StatePublished - Oct 19 2010

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Mammals
Drosophila
Tissue homeostasis
Phosphotransferases
Neoplasms
Organ Size
Oncogene Proteins
Physiology
Cell proliferation
Tumors
Cell Survival
Animals
Homeostasis
Genes
Cell Proliferation

ASJC Scopus subject areas

  • Developmental Biology

Cite this

The hippo signaling pathway in development and cancer. / Pan, Duojia.

In: Developmental Cell, Vol. 19, No. 4, 19.10.2010, p. 491-505.

Research output: Contribution to journalReview article

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