The hyperleptinemia of obesity - Regulator of caloric surpluses

Roger H Unger

Research output: Contribution to journalReview articlepeer-review

62 Scopus citations

Abstract

New evidence suggests that leptin and other anorexigenic agents reduce appetite by inactivating hypothalamic AMP-activated protein kinase (AMPK), thereby increasing malonyl CoA levels. This preview examines AMP biology and its role in malonyl-CoA generation and attempts to integrate its central actions with its peripheral antilipotoxic actions within the context of leptin physiology in obesity.

Original languageEnglish (US)
Pages (from-to)145-146
Number of pages2
JournalCell
Volume117
Issue number2
DOIs
StatePublished - Apr 16 2004

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'The hyperleptinemia of obesity - Regulator of caloric surpluses'. Together they form a unique fingerprint.

Cite this