The hyperleptinemia of obesity - Regulator of caloric surpluses

Roger H Unger

doi:10.1016/S0092-8674(04)00339-3

The hyperleptinemia of obesity - Regulator of caloric surpluses

Roger H Unger

Research output: Contribution to journal › Review article › peer-review

66 Scopus citations

Abstract

New evidence suggests that leptin and other anorexigenic agents reduce appetite by inactivating hypothalamic AMP-activated protein kinase (AMPK), thereby increasing malonyl CoA levels. This preview examines AMP biology and its role in malonyl-CoA generation and attempts to integrate its central actions with its peripheral antilipotoxic actions within the context of leptin physiology in obesity.

Original language	English (US)
Pages (from-to)	145-146
Number of pages	2
Journal	Cell
Volume	117
Issue number	2
DOIs	https://doi.org/10.1016/S0092-8674(04)00339-3
State	Published - Apr 16 2004

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/S0092-8674(04)00339-3

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abstract = "New evidence suggests that leptin and other anorexigenic agents reduce appetite by inactivating hypothalamic AMP-activated protein kinase (AMPK), thereby increasing malonyl CoA levels. This preview examines AMP biology and its role in malonyl-CoA generation and attempts to integrate its central actions with its peripheral antilipotoxic actions within the context of leptin physiology in obesity.",

author = "Unger, {Roger H}",

note = "Funding Information: This study was supported by NIDDK-02700 and the Department of Veterans Affairs Merit Review #824-103. We thank Cai Li, PhD, for helpful suggestions and Jim Hardy and Kay McCorkle at the Department of Veterans Affairs for figure illustration. ",

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The hyperleptinemia of obesity - Regulator of caloric surpluses

Abstract

ASJC Scopus subject areas

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