The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development

Hui Tian, Robert E Hammer, Alvin M. Matsumoto, David W Russell, Steven L McKnight

Research output: Contribution to journalArticle

470 Scopus citations

Abstract

Mice lacking the hypoxia-inducible transcription factor EPAS1 die at mid-gestation. Despite normal morphological development of the circulatory system, EPAS1-deficient mice display pronounced bradycardia. In addition to the vascular endothelium, EPAS1 is expressed intensively in the organ of Zuckerkandl (OZ), the principle source of catecholamine production in mammalian embryos. EPAS1-deficient embryos contained substantially reduced catecholamine levels. Mid-gestational lethality was rescued by administration of the catecholamine precursor DOPS to pregnant females. We hypothesize that EPAS1 expressed in the OZ senses hypoxia during midgestational development and translates this signal into an altered pattern of gene expression, leading to increases in circulating catecholamine levels and proper cardiac function.

Original languageEnglish (US)
Pages (from-to)3320-3324
Number of pages5
JournalGenes and Development
Volume12
Issue number21
DOIs
StatePublished - Nov 1 1998

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Keywords

  • EPAS1
  • Gene targeting
  • Hypoxia

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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