The impact of utilizing different optical coherence tomography devices for clinical purposes and in multiple sclerosis trials

Christina V. Warner, Stephanie B. Syc, Aleksandra M. Stankiewicz, Girish Hiremath, Sheena K. Farrell, Ciprian M. Crainiceanu, Amy Conger, Teresa C. Frohman, Esther R. Bisker, Laura J. Balcer, Elliot Frohman, Peter A. Calabresi, Shiv Saidha

Research output: Contribution to journalArticle

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Abstract

Optical coherence tomography (OCT) derived retinal measures, particularly peri-papillary retinal nerve fiber layer (RNFL) thickness, have been proposed as outcome measures in remyelinating and neuroprotective trials in multiple sclerosis (MS). With increasing utilization of multiple centers to improve power, elucidation of the impact of different OCT technologies is crucial to the design and interpretation of such studies. In this study, we assessed relation and agreement between RNFL thickness and total macular volume (in MS and healthy controls) derived from three commonly used OCT devices: Stratus time-domain OCT, and Cirrus HD-OCT and Spectralis, two spectral-domain (SD) OCT devices. OCT was performed on both Cirrus HD-OCT and Stratus in 229 participants and on both Cirrus HD-OCT and Spectralis in a separate cohort of 102 participants. Pearson correlation and Bland-Altman analyses were used to assess correlation and agreement between devices. All OCT retinal measures correlated highly between devices. The mean RNFL thickness was 7.4 μm lower on Cirrus HD-OCT than Stratus, indicating overall poor agreement for this measurement between these machines. Further, the limits of agreement (LOA) between Cirrus HD-OCT and Stratus were wide (-4.1 to 18.9 μm), indicating poor agreement at an individual subject level. The mean RNFL thickness was 1.94 μm (LOA: -5.74 to 9.62 μm) higher on Spectralis compared to Cirrus HD-OCT, indicating excellent agreement for this measurement across this cohort. Although these data indicate that these three devices agree poorly at an individual subject level (evidenced by wide LOA in both study cohorts) precluding their co-utilization in everyday practice, the small difference for mean measurements between Cirrus HD-OCT and Spectralis indicate pooled results from these two SD-devices could be used as outcome measures in clinical trials, provided patients are scanned on the same machine throughout the trial, similar to the utilization of multiple different MRI platforms in MS clinical trials.

Original languageEnglish (US)
Article numbere22947
JournalPLoS One
Volume6
Issue number8
DOIs
StatePublished - 2011

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Optical tomography
tomography
Optical Coherence Tomography
sclerosis
Multiple Sclerosis
Equipment and Supplies
nerve fibers
Nerve Fibers
Fibers
clinical trials
Outcome Assessment (Health Care)
Clinical Trials
cohort studies
Magnetic resonance imaging
Cohort Studies

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Warner, C. V., Syc, S. B., Stankiewicz, A. M., Hiremath, G., Farrell, S. K., Crainiceanu, C. M., ... Saidha, S. (2011). The impact of utilizing different optical coherence tomography devices for clinical purposes and in multiple sclerosis trials. PLoS One, 6(8), [e22947]. https://doi.org/10.1371/journal.pone.0022947

The impact of utilizing different optical coherence tomography devices for clinical purposes and in multiple sclerosis trials. / Warner, Christina V.; Syc, Stephanie B.; Stankiewicz, Aleksandra M.; Hiremath, Girish; Farrell, Sheena K.; Crainiceanu, Ciprian M.; Conger, Amy; Frohman, Teresa C.; Bisker, Esther R.; Balcer, Laura J.; Frohman, Elliot; Calabresi, Peter A.; Saidha, Shiv.

In: PLoS One, Vol. 6, No. 8, e22947, 2011.

Research output: Contribution to journalArticle

Warner, CV, Syc, SB, Stankiewicz, AM, Hiremath, G, Farrell, SK, Crainiceanu, CM, Conger, A, Frohman, TC, Bisker, ER, Balcer, LJ, Frohman, E, Calabresi, PA & Saidha, S 2011, 'The impact of utilizing different optical coherence tomography devices for clinical purposes and in multiple sclerosis trials', PLoS One, vol. 6, no. 8, e22947. https://doi.org/10.1371/journal.pone.0022947
Warner, Christina V. ; Syc, Stephanie B. ; Stankiewicz, Aleksandra M. ; Hiremath, Girish ; Farrell, Sheena K. ; Crainiceanu, Ciprian M. ; Conger, Amy ; Frohman, Teresa C. ; Bisker, Esther R. ; Balcer, Laura J. ; Frohman, Elliot ; Calabresi, Peter A. ; Saidha, Shiv. / The impact of utilizing different optical coherence tomography devices for clinical purposes and in multiple sclerosis trials. In: PLoS One. 2011 ; Vol. 6, No. 8.
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abstract = "Optical coherence tomography (OCT) derived retinal measures, particularly peri-papillary retinal nerve fiber layer (RNFL) thickness, have been proposed as outcome measures in remyelinating and neuroprotective trials in multiple sclerosis (MS). With increasing utilization of multiple centers to improve power, elucidation of the impact of different OCT technologies is crucial to the design and interpretation of such studies. In this study, we assessed relation and agreement between RNFL thickness and total macular volume (in MS and healthy controls) derived from three commonly used OCT devices: Stratus time-domain OCT, and Cirrus HD-OCT and Spectralis, two spectral-domain (SD) OCT devices. OCT was performed on both Cirrus HD-OCT and Stratus in 229 participants and on both Cirrus HD-OCT and Spectralis in a separate cohort of 102 participants. Pearson correlation and Bland-Altman analyses were used to assess correlation and agreement between devices. All OCT retinal measures correlated highly between devices. The mean RNFL thickness was 7.4 μm lower on Cirrus HD-OCT than Stratus, indicating overall poor agreement for this measurement between these machines. Further, the limits of agreement (LOA) between Cirrus HD-OCT and Stratus were wide (-4.1 to 18.9 μm), indicating poor agreement at an individual subject level. The mean RNFL thickness was 1.94 μm (LOA: -5.74 to 9.62 μm) higher on Spectralis compared to Cirrus HD-OCT, indicating excellent agreement for this measurement across this cohort. Although these data indicate that these three devices agree poorly at an individual subject level (evidenced by wide LOA in both study cohorts) precluding their co-utilization in everyday practice, the small difference for mean measurements between Cirrus HD-OCT and Spectralis indicate pooled results from these two SD-devices could be used as outcome measures in clinical trials, provided patients are scanned on the same machine throughout the trial, similar to the utilization of multiple different MRI platforms in MS clinical trials.",
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