The importance of cytochrome p450 monooxygenase CYP2D6 in palliative medicine

Mellar P. Davis, Jade Homsi

Research output: Contribution to journalReview article

49 Scopus citations

Abstract

The enzymes in the cytochrome p450 monooxygenase system (CYP) are the major enzymes responsible for metabolizing medications. The CYP2D6 isomer is responsible for metabolizing certain opioids, neuroleptics, antidepressants and cardiac medications. Owing to CYP2D6's low capacity and high affinity it is easily saturated by substrate and/or inhibited, resulting in pharmacokinetic interactions. Polymorphisms of the structural gene are common, leading to wide inter-individual and ethnic differences in drug metabolism. Clinically important drug interactions, which may be anticipated in the palliative medicine population, are reviewed.

Original languageEnglish (US)
Pages (from-to)442-451
Number of pages10
JournalSupportive Care in Cancer
Volume9
Issue number6
DOIs
StatePublished - Jan 1 2001

Keywords

  • CYP2D6
  • Drug interactions
  • Drug metabolism
  • Ethnic differences
  • Palliative medicine
  • Pharmacokinetics

ASJC Scopus subject areas

  • Oncology

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