TY - JOUR
T1 - The induction of temperature-sensitive mutations in Drosophila melanogaster by the acridine mustard ICR-170
AU - Woodruff, R. C.
AU - Gander, Rita M.
PY - 1974/12
Y1 - 1974/12
N2 - The monofunctional quinacrine mustard ICR-170 (2-methoxy-6-chloro-9-(3-[ethyl-2-chloroethyl] aminopropylamino) acridine dihydrochloride) has been observed to induce temperature-sensitive recessive sex-linked mutations in Drosophila melanogaster. Out of a total of 122 lethals recovered, five proved to be heat sensitive, one heat and cold sensitive, and one cold sensitive. This observation, plus the recovery of some leaky temperature-sensitive mutations, indicates that in Drosophila melanogaster ICR-170 may function by inducing some base-pair substitution mutations, probably by action of its alkylating nitrogen mustard moiety.
AB - The monofunctional quinacrine mustard ICR-170 (2-methoxy-6-chloro-9-(3-[ethyl-2-chloroethyl] aminopropylamino) acridine dihydrochloride) has been observed to induce temperature-sensitive recessive sex-linked mutations in Drosophila melanogaster. Out of a total of 122 lethals recovered, five proved to be heat sensitive, one heat and cold sensitive, and one cold sensitive. This observation, plus the recovery of some leaky temperature-sensitive mutations, indicates that in Drosophila melanogaster ICR-170 may function by inducing some base-pair substitution mutations, probably by action of its alkylating nitrogen mustard moiety.
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U2 - 10.1016/0027-5107(74)90062-1
DO - 10.1016/0027-5107(74)90062-1
M3 - Article
C2 - 4215971
AN - SCOPUS:0016246711
SN - 0027-5107
VL - 25
SP - 337
EP - 345
JO - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
JF - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
IS - 3
ER -