The monofunctional quinacrine mustard ICR-170 (2-methoxy-6-chloro-9-(3-[ethyl-2-chloroethyl] aminopropylamino) acridine dihydrochloride) has been observed to induce temperature-sensitive recessive sex-linked mutations in Drosophila melanogaster. Out of a total of 122 lethals recovered, five proved to be heat sensitive, one heat and cold sensitive, and one cold sensitive. This observation, plus the recovery of some leaky temperature-sensitive mutations, indicates that in Drosophila melanogaster ICR-170 may function by inducing some base-pair substitution mutations, probably by action of its alkylating nitrogen mustard moiety.
|Original language||English (US)|
|Number of pages||9|
|Journal||Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis|
|State||Published - Dec 1974|
ASJC Scopus subject areas
- Molecular Biology
- Health, Toxicology and Mutagenesis