The Interaction between Lymphoid Tissue Inducer-Like Cells and T Cells in the Mesenteric Lymph Node Restrains Intestinal Humoral Immunity

Wenyan Wang, Yiping Li, Jiacheng Hao, Yao He, Xin Dong, Yang Xin Fu, Xiaohuan Guo

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Wang et al. report that lymphoid-tissue-inducer (LTi)-like cells from different tissues display heterogeneity. The maintenance of LTi-like cells in the mLN requires RANKL signaling from CD4+ T cells. LTi-like cells from the mLN control Tfh and subsequent humoral responses during intestinal immunization in an ID2- and PD-L1-dependent manner.

Original languageEnglish (US)
Article number107936
JournalCell Reports
Volume32
Issue number3
DOIs
StatePublished - Jul 21 2020

Keywords

  • ID2
  • LTi-like cell
  • PD-L1
  • RANKL
  • T follicular helper cell

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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