Wang et al. report that lymphoid-tissue-inducer (LTi)-like cells from different tissues display heterogeneity. The maintenance of LTi-like cells in the mLN requires RANKL signaling from CD4+ T cells. LTi-like cells from the mLN control Tfh and subsequent humoral responses during intestinal immunization in an ID2- and PD-L1-dependent manner.
- LTi-like cell
- T follicular helper cell
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)