The interference of ascorbic acid in sensitive detection of dopamine by a non-oxidative sensing approach

Rishi R. Parajuli, Shah R. Ali, Yufeng Ma, Yetunde Balogun, Huixin He

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Determination of Dopamine electrochemically by direct oxidation is difficult due to the co-oxidation of ascorbic acid present in high concentration in biological fluids in the same potential window. In this report, we present a non oxidative approach to electrochemically detect dopamine with high selectivity and sensitivity using our newly developed poly (anilineboronic acid) composite with single walled carbon nanotubes. The mechanism of interference by ascorbic acid was studied and the results showed that ascorbic acid interacted with poly (anilineboronic acid) both chemically and electrocatalytically due to its multi-functional diol motif. An association constant between ascorbic acid and phenylboronic acid was determined to quantitate the strength of the interaction between the two molecules. By depositing a layer of permselective ionomer Nafion on top of the composite, the sensor can selectively detect dopamine in pM∼ nm range. The high sensitivity along with the improved selectivity of this approach might have potential application toward molecular diagnosis of Parkinson's disease.

Original languageEnglish (US)
Title of host publication2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings
Pages523-526
Number of pages4
StatePublished - 2007
Externally publishedYes
Event2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007 - Santa Clara, CA, United States
Duration: May 20 2007May 24 2007

Publication series

Name2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings
Volume2

Conference

Conference2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007
Country/TerritoryUnited States
CitySanta Clara, CA
Period5/20/075/24/07

Keywords

  • Dopamine
  • Polyaniline; carbon nanotubes; ascorbic acid; interference; neurotransmitter

ASJC Scopus subject areas

  • Mechanical Engineering

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