The Kto-Skd complex can regulate ptc expression by interacting with Cubitus interruptus (Ci) in the hedgehog signaling pathway

Feifei Mao, Xiaofeng Yang, Lin Fu, Xiangdong Lv, Zhao Zhang, Wenqing Wu, Siqi Yang, Zhaocai Zhou, Lei Zhang, Yun Zhao

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Background: Kto-Skd plays important roles in development. But the mechanism for how this complex regulates Hedgehog pathway is unknown. Results: Kto-Skd down-regulates ptc expression. Conclusion: Kto-Skd complex can regulate ptc expression by interacting with Ci. Significance: The finding that the Kto-Skd complex affects Hh pathway provides novel mechanistic insights into the regulation of A/P boundary formation in Drosophila wing discs.

Original languageEnglish (US)
Pages (from-to)22333-22341
Number of pages9
JournalJournal of Biological Chemistry
Volume289
Issue number32
DOIs
StatePublished - Aug 8 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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