The LDL receptor gene family: Signaling functions during development

Brian W. Howell, Joachim Herz

Research output: Contribution to journalReview article

66 Scopus citations

Abstract

The traditional views regarding the biological functions of the low-density lipoprotein (LDL) receptor gene family have been revisited recently with new evidence that at least some of the members of this receptor family act as signal-transduction molecules. Known for their role in endocytosis, particularly of their namesake the LDLs, and for their role in the prevention of atherosclerosis, these receptors belong to an ancient family with numerous ligands, effector molecules and functions. Recent evidence implicates this family of receptors in diverse signaling pathways, long-term potentiation and neuronal degeneration.

Original languageEnglish (US)
Pages (from-to)74-81
Number of pages8
JournalCurrent Opinion in Neurobiology
Volume11
Issue number1
DOIs
StatePublished - 2001

ASJC Scopus subject areas

  • Neuroscience(all)

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