TY - JOUR
T1 - The LDL receptor gene family
T2 - Signaling functions during development
AU - Howell, Brian W.
AU - Herz, Joachim
N1 - Funding Information:
Supported by grants from the National Institutes of Health, the Human Frontier Science Program, the Alzheimer Organization, and the Perot Family Foundation. J Herz is an Established Investigator of the American Heart Association and Parke-Davis.
PY - 2001
Y1 - 2001
N2 - The traditional views regarding the biological functions of the low-density lipoprotein (LDL) receptor gene family have been revisited recently with new evidence that at least some of the members of this receptor family act as signal-transduction molecules. Known for their role in endocytosis, particularly of their namesake the LDLs, and for their role in the prevention of atherosclerosis, these receptors belong to an ancient family with numerous ligands, effector molecules and functions. Recent evidence implicates this family of receptors in diverse signaling pathways, long-term potentiation and neuronal degeneration.
AB - The traditional views regarding the biological functions of the low-density lipoprotein (LDL) receptor gene family have been revisited recently with new evidence that at least some of the members of this receptor family act as signal-transduction molecules. Known for their role in endocytosis, particularly of their namesake the LDLs, and for their role in the prevention of atherosclerosis, these receptors belong to an ancient family with numerous ligands, effector molecules and functions. Recent evidence implicates this family of receptors in diverse signaling pathways, long-term potentiation and neuronal degeneration.
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U2 - 10.1016/S0959-4388(00)00176-8
DO - 10.1016/S0959-4388(00)00176-8
M3 - Review article
C2 - 11179875
AN - SCOPUS:0035252879
VL - 11
SP - 74
EP - 81
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
SN - 0959-4388
IS - 1
ER -