The low density lipoprotein pathway in human fibroblasts

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Abstract

Recent studies indicate that low density lipoprotein is ingested by human fibroblasts in a process kinetically similar to adsorptive endocytosis. Patients lacking the necessary cell surface receptor, Familial Hypercholesterolemia homozygotes, have a defective uptake of low density lipoprotein, consequently impaired regulation of cholesterol synthesis and develop hypercholesterolemia and fulminant atherosclerosis.

Original languageEnglish (US)
Pages (from-to)193-195
Number of pages3
JournalTrends in Biochemical Sciences
Volume1
Issue number9
DOIs
Publication statusPublished - 1976

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ASJC Scopus subject areas

  • Biochemistry

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