The management of Giardiasis

C. J. Vesy, W. L. Peterson

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Giardiasis is the intestinal infection resulting from infestation with the human parasite Giardia intestinalis, also called Giardia lamblia. The infection may be asymptomatic or present with a variety of symptoms such as diarrhoea, weight loss, abdominal cramps, and failure to thrive. Giardiasis is most often diagnosed after recent travel or in day care centres. The organism has two stages in its life cycle. It is usually ingested as a cyst with as few as 10-25 cysts being sufficient to cause infection. After excystation, the organism is a replicative trophozoite which may attach to the small bowel wall. Giardia intestinalis does not invade the bowel wall. Trophozoites may encyst and be shed in faeces for future ingestion by another host. Diagnosis of infection is by stool examination which may also eliminate other possible infectious agents. Small bowel biopsy may be necessary in difficult individual cases or to rule out non-infectious illnesses, and stool ELISA may serve for large population screening examinations. The mainstay of treatment is metronidazole 250-400 mg three times per day by mouth for 5 days.

Original languageEnglish (US)
Pages (from-to)843-850
Number of pages8
JournalAlimentary Pharmacology and Therapeutics
Volume13
Issue number7
DOIs
StatePublished - 1999

Fingerprint

Giardiasis
Giardia lamblia
Trophozoites
Infection
Cysts
Failure to Thrive
Colic
Metronidazole
Life Cycle Stages
Feces
Mouth
Weight Loss
Diarrhea
Parasites
Eating
Enzyme-Linked Immunosorbent Assay
Biopsy
Population

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

The management of Giardiasis. / Vesy, C. J.; Peterson, W. L.

In: Alimentary Pharmacology and Therapeutics, Vol. 13, No. 7, 1999, p. 843-850.

Research output: Contribution to journalArticle

Vesy, C. J. ; Peterson, W. L. / The management of Giardiasis. In: Alimentary Pharmacology and Therapeutics. 1999 ; Vol. 13, No. 7. pp. 843-850.
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