The many ways to make a luminal cell and a prostate cancer cell

Douglas W. Strand, Andrew S. Goldstein

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Research in the area of stem/progenitor cells has led to the identification of multiple stemlike cell populations implicated in prostate homeostasis and cancer initiation. Given that there are multiple cells that can regenerate prostatic tissue and give rise to prostate cancer, our focus should shift to defining the signaling mechanisms that drive differentiation and progenitor self-renewal. In this article, we will review the literature, present the evidence and raise important unanswered questions that will help guide the field forward in dissecting critical mechanisms regulating stem-cell differentiation and tumor initiation.

Original languageEnglish (US)
Pages (from-to)T187-T197
JournalEndocrine-Related Cancer
Volume22
Issue number6
DOIs
StatePublished - Dec 1 2015

Fingerprint

Prostatic Neoplasms
Stem Cells
Cell Differentiation
Homeostasis
Research
Population
Neoplasms

Keywords

  • Carcinoma
  • Prostate

ASJC Scopus subject areas

  • Endocrinology
  • Oncology
  • Cancer Research
  • Endocrinology, Diabetes and Metabolism

Cite this

The many ways to make a luminal cell and a prostate cancer cell. / Strand, Douglas W.; Goldstein, Andrew S.

In: Endocrine-Related Cancer, Vol. 22, No. 6, 01.12.2015, p. T187-T197.

Research output: Contribution to journalArticle

Strand, Douglas W. ; Goldstein, Andrew S. / The many ways to make a luminal cell and a prostate cancer cell. In: Endocrine-Related Cancer. 2015 ; Vol. 22, No. 6. pp. T187-T197.
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