TY - JOUR
T1 - The metabolism of (-) octanoylcarnitine in perfused livers from fed and fasted rats. Evidence for a possible regulatory role of carnitine acyltransferase in the control of ketogenesis
AU - McGarry, J. D.
AU - Foster, D. W.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1974
Y1 - 1974
N2 - In confirmation of previous findings it was shown that perfused livers from fasted rats converted oleic acid into ketone bodies far more efficiently than did livers from fed animals, whereas differences in rates of ketogenesis from octanoate were much less pronounced. However, relative rates of ketone body production from (-)-octanoylcarnitine resembled those seen with oleic acid rather than those obtained with free octanoic acid as substrate. In addition (+)-octanoylcarnitine, an inhibitor of carnitine acyltransferase, was without effect on the oxidation of octanoic acid, but caused a profound and quantitatively similar depression in the oxidation of both oleic acid and (-)-octanoylcarnitine. The data support the concept that the carnitine acyltransferase system of liver is under strict dietary, or hormonal control, or both, and that it may constitute a primary site for the regulation of hepatic fatty acid oxidation and ketogenesis.
AB - In confirmation of previous findings it was shown that perfused livers from fasted rats converted oleic acid into ketone bodies far more efficiently than did livers from fed animals, whereas differences in rates of ketogenesis from octanoate were much less pronounced. However, relative rates of ketone body production from (-)-octanoylcarnitine resembled those seen with oleic acid rather than those obtained with free octanoic acid as substrate. In addition (+)-octanoylcarnitine, an inhibitor of carnitine acyltransferase, was without effect on the oxidation of octanoic acid, but caused a profound and quantitatively similar depression in the oxidation of both oleic acid and (-)-octanoylcarnitine. The data support the concept that the carnitine acyltransferase system of liver is under strict dietary, or hormonal control, or both, and that it may constitute a primary site for the regulation of hepatic fatty acid oxidation and ketogenesis.
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M3 - Article
C2 - 4430681
AN - SCOPUS:0016163592
SN - 0021-9258
VL - 249
SP - 7984
EP - 7990
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 24
ER -