The microtubule associated protein tau H1 haplotype and risk of essential tremor

L. N. Clark, X. Liu, N. L. Parmalee, N. Hernandez, E. D. Louis

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Background and purpose: Two recent studies investigated the association of the microtubule associated protein tau (MAPT) H1 haplotype, a known risk factor for neurodegenerative disease including progressive supranuclear palsy and Parkinson's disease (PD), with essential tremor (ET). Methods: To confirm this association in a different population the distribution of allele and genotype frequencies for the MAPT H1/H2 tagging single-nucleotide polymorphism (SNP) rs1052553 in ET cases and controls enrolled in a clinical-epidemiological study of ET at Columbia University was analyzed. Results: Overall, no association was observed between ET and the MAPT H1 haplotype. The analysis was also restricted to clinical subtypes including early-onset (≤40 years of age), Ashkenazi Jewish ancestry, white non-Ashkenazi, or ET cases with a 'definite' or 'probable/possible' diagnosis; none of these stratified analyses showed evidence of association with ET. A meta-analysis of the H1/H2 tagging SNP rs1052553 in published data sets and the H1 haplotype with risk for ET in the current study was also performed and did not find evidence for association. Conclusions: The inconsistent reports of association of MAPT H1 in three emerging studies (our own and two published studies) may reflect sampling issues and/or clinical heterogeneity in these populations.

Original languageEnglish (US)
Pages (from-to)1044-1048
Number of pages5
JournalEuropean Journal of Neurology
Volume21
Issue number7
DOIs
StatePublished - Jul 2014
Externally publishedYes

Keywords

  • Candidate genes
  • Case-control study
  • Essential tremor
  • Microtubule associated protein tau
  • Single nucleotide polymorphisms

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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