TY - JOUR
T1 - The molecular and genetic basis of neurological tumours
AU - Zhu, Yuan
AU - Parada, Luis F.
N1 - Funding Information:
The authors thank D. Burns, S. Kernie and L. Klesse for critically reading the manuscript. They also thank the members of the Parada lab for helpful discussions. L.F.P. is supported by NINDS (National Institute of Neurological Disorders and Stroke) and DOD (Department of Defence) grants. Y.Z. is a recipient of a Young Investigator Award from the NNFF (National Neurofibromatosis Foundation).
PY - 2002/8
Y1 - 2002/8
N2 - There are no effective therapies for many tumours of the nervous system. This is, in part, a consequence of their location within relatively inaccessible tissues. It is also likely, however, that the unique characteristics of the cells that give rise to these tumours create a set of conditions that facilitate tumour development. Here, we consider recent advances in molecular genetics, the development of mouse models and developmental neurobiology as they relate to tumours of neuroectodermal origin. It is likely that these advances will provide insight into underlying mechanisms and provide a rational framework for the development of effective interventions.
AB - There are no effective therapies for many tumours of the nervous system. This is, in part, a consequence of their location within relatively inaccessible tissues. It is also likely, however, that the unique characteristics of the cells that give rise to these tumours create a set of conditions that facilitate tumour development. Here, we consider recent advances in molecular genetics, the development of mouse models and developmental neurobiology as they relate to tumours of neuroectodermal origin. It is likely that these advances will provide insight into underlying mechanisms and provide a rational framework for the development of effective interventions.
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U2 - 10.1038/nrc866
DO - 10.1038/nrc866
M3 - Review article
C2 - 12154354
AN - SCOPUS:0036675901
SN - 1474-175X
VL - 2
SP - 616
EP - 626
JO - Nature Reviews Cancer
JF - Nature Reviews Cancer
IS - 8
ER -