The molecular and genetic basis of neurological tumours

Yuan Zhu, Luis F. Parada

Research output: Contribution to journalArticle

228 Citations (Scopus)

Abstract

There are no effective therapies for many tumours of the nervous system. This is, in part, a consequence of their location within relatively inaccessible tissues. It is also likely, however, that the unique characteristics of the cells that give rise to these tumours create a set of conditions that facilitate tumour development. Here, we consider recent advances in molecular genetics, the development of mouse models and developmental neurobiology as they relate to tumours of neuroectodermal origin. It is likely that these advances will provide insight into underlying mechanisms and provide a rational framework for the development of effective interventions.

Original languageEnglish (US)
Pages (from-to)616-626
Number of pages11
JournalNature Reviews Cancer
Volume2
Issue number8
DOIs
StatePublished - Aug 2002

Fingerprint

Molecular Biology
Neuroectodermal Tumors
Nervous System Neoplasms
Neurobiology
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Cancer Research

Cite this

The molecular and genetic basis of neurological tumours. / Zhu, Yuan; Parada, Luis F.

In: Nature Reviews Cancer, Vol. 2, No. 8, 08.2002, p. 616-626.

Research output: Contribution to journalArticle

Zhu, Yuan ; Parada, Luis F. / The molecular and genetic basis of neurological tumours. In: Nature Reviews Cancer. 2002 ; Vol. 2, No. 8. pp. 616-626.
@article{15d3e338636744f3a6ecd84cbbaafee2,
title = "The molecular and genetic basis of neurological tumours",
abstract = "There are no effective therapies for many tumours of the nervous system. This is, in part, a consequence of their location within relatively inaccessible tissues. It is also likely, however, that the unique characteristics of the cells that give rise to these tumours create a set of conditions that facilitate tumour development. Here, we consider recent advances in molecular genetics, the development of mouse models and developmental neurobiology as they relate to tumours of neuroectodermal origin. It is likely that these advances will provide insight into underlying mechanisms and provide a rational framework for the development of effective interventions.",
author = "Yuan Zhu and Parada, {Luis F.}",
year = "2002",
month = "8",
doi = "10.1038/nrc866",
language = "English (US)",
volume = "2",
pages = "616--626",
journal = "Nature Reviews Cancer",
issn = "1474-175X",
publisher = "Nature Publishing Group",
number = "8",

}

TY - JOUR

T1 - The molecular and genetic basis of neurological tumours

AU - Zhu, Yuan

AU - Parada, Luis F.

PY - 2002/8

Y1 - 2002/8

N2 - There are no effective therapies for many tumours of the nervous system. This is, in part, a consequence of their location within relatively inaccessible tissues. It is also likely, however, that the unique characteristics of the cells that give rise to these tumours create a set of conditions that facilitate tumour development. Here, we consider recent advances in molecular genetics, the development of mouse models and developmental neurobiology as they relate to tumours of neuroectodermal origin. It is likely that these advances will provide insight into underlying mechanisms and provide a rational framework for the development of effective interventions.

AB - There are no effective therapies for many tumours of the nervous system. This is, in part, a consequence of their location within relatively inaccessible tissues. It is also likely, however, that the unique characteristics of the cells that give rise to these tumours create a set of conditions that facilitate tumour development. Here, we consider recent advances in molecular genetics, the development of mouse models and developmental neurobiology as they relate to tumours of neuroectodermal origin. It is likely that these advances will provide insight into underlying mechanisms and provide a rational framework for the development of effective interventions.

UR - http://www.scopus.com/inward/record.url?scp=0036675901&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036675901&partnerID=8YFLogxK

U2 - 10.1038/nrc866

DO - 10.1038/nrc866

M3 - Article

C2 - 12154354

AN - SCOPUS:0036675901

VL - 2

SP - 616

EP - 626

JO - Nature Reviews Cancer

JF - Nature Reviews Cancer

SN - 1474-175X

IS - 8

ER -