The mouse Clock mutation behaves as an antimorph and maps within the W(19H) deletion, distal of Kit

David P. King, Martha Hotz Vitaterna, Anne Marie Chang, William F. Dove, Lawrence H. Pinto, Fred W. Turek, Joseph S. Takahashi

Research output: Contribution to journalArticle

120 Scopus citations

Abstract

Clock is a semidominant mutation identified from an N-ethyl-N- nitrosourea mutagenesis screen in mice. Mice carrying the clock mutation exhibit abnormalities of circadian behavior, including lengthening of endogenous period and loss of rhythmicity. To identify the gene affected by this mutation, we have generated a high-resolution genetic map (>1800 meioses) of the Clock locus. We report that Clock is 0.7 cM distal of Kit on mouse chromosome 5. Mapping shows that Clock lies within the W(19H) deletion. Complementation analysis of different Clock and W(19H) compound genotypes indicates that the Clock mutation behaves as an antimorph. This antimorphic behavior of Clock strongly argues that Clock defines a gene centrally involved in the mammalian circadian system.

Original languageEnglish (US)
Pages (from-to)1049-1060
Number of pages12
JournalGenetics
Volume146
Issue number3
StatePublished - Jul 23 1997

ASJC Scopus subject areas

  • Genetics

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    King, D. P., Vitaterna, M. H., Chang, A. M., Dove, W. F., Pinto, L. H., Turek, F. W., & Takahashi, J. S. (1997). The mouse Clock mutation behaves as an antimorph and maps within the W(19H) deletion, distal of Kit. Genetics, 146(3), 1049-1060.