The multifunctional role of transforming growth factor (TGF)-ßs on mammary epithelial cell biology

Carlos L. Arteaga, Teresa C. Dugger, Stephen D. Hurd

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

The transforming growth factor-βs are potent growth inhibitors of normal and transformed breast epithelial cells in culture. In vivo, these peptides modulate the development of the mouse mammary gland. Tissue-specific overexpression of mature TGF-β1 in transgenic mice results in mammary gland atrophy and prevention of carcinogen-induced breast tumorigenesis. However, the inhibitory effect of endogenous or exogenous TGF-βs on established tumor cells is less clear. Several published circumstantial and more direct data argue that, in some cases, the tumor cell TGF-βs may contribute to the maintenance and/or progression of tumor cells in an intact host by modulating their interaction with host factors. This differential role of the TGF-βs on mammary cells as determined by their normal or transformed phenotype as well as the biological and clinical implications of these data are discussed.

Original languageEnglish (US)
Pages (from-to)49-56
Number of pages8
JournalBreast Cancer Research and Treatment
Volume38
Issue number1
DOIs
StatePublished - 1996

Keywords

  • Breast carcinoma
  • Mammary epithelium
  • Natural killer activity
  • Transforming growth factor-βs

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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