The nature of pressor responsiveness to angiotensin II in human pregnancy

N. F. Gant, S. Chand, P. J. Whalley, P. C. Macdonald

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

This investigation studied the determinants of the pressor response to infused angiotensin II in normal pregnant women near term. In these subjects acute plasma volume expansion was accomplished by the rapid intravenous infusion of normal saline or 6% dextran. This treatment was uniformly effective in reducing the venous hematocrit and plasma renin activity but failed to alter the amount of intravenously infused angiotensin II dose required to elicit a pressor response. The same treatment of nonpregnant women resulted in a marked decrease in the dose of angiotensin II required to elicit the same pressor response after volume expansion compared to that required before. The rapid infusion of the same amount of NaCl as a 5% solution to normal pregnant women near term resulted in a marked decrease in angiotensin II pressor resistance. The results suggest that the principal determinant of pressor response to angiotensin II in pregnancy is arteriole response and not alterations in plasma volume or renin plasma levels.

Original languageEnglish (US)
Pages (from-to)854-860
Number of pages7
JournalObstetrics and Gynecology
Volume43
Issue number6
StatePublished - 1974

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Angiotensin II
Pregnancy
Plasma Volume
Renin
Pregnant Women
Arterioles
Dextrans
Hematocrit
Intravenous Infusions
Therapeutics

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

The nature of pressor responsiveness to angiotensin II in human pregnancy. / Gant, N. F.; Chand, S.; Whalley, P. J.; Macdonald, P. C.

In: Obstetrics and Gynecology, Vol. 43, No. 6, 1974, p. 854-860.

Research output: Contribution to journalArticle

Gant, NF, Chand, S, Whalley, PJ & Macdonald, PC 1974, 'The nature of pressor responsiveness to angiotensin II in human pregnancy', Obstetrics and Gynecology, vol. 43, no. 6, pp. 854-860.
Gant, N. F. ; Chand, S. ; Whalley, P. J. ; Macdonald, P. C. / The nature of pressor responsiveness to angiotensin II in human pregnancy. In: Obstetrics and Gynecology. 1974 ; Vol. 43, No. 6. pp. 854-860.
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