The nervous system and chronic kidney disease in children

Debbie S. Gipson, Crista E. Wetherington, Peter J. Duquette, Stephen R. Hooper

Research output: Contribution to journalReview articlepeer-review

40 Scopus citations


This paper provides a review of the literature on the nervous system involvement incurred by children and adolescents with chronic kidney disease (CKD), with a particular focus on neuropsychological functioning. In addition to an historical overview of earlier literature, published studies from the past 14 years that address both central and peripheral nervous system function in children with CKD are reviewed (1990-2003). These studies span work in neuroimaging, electrophysiology, and neuropsychology. A key focus for this review is on variables that might affect neurodevelopmental status in these children. The paper concludes with suggestions for achieving progress in the understanding of this complication of kidney disease in children.

Original languageEnglish (US)
Pages (from-to)832-839
Number of pages8
JournalPediatric Nephrology
Issue number8
StatePublished - Aug 2004


  • Cognition
  • Neurodevelopment
  • Renal failure

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology


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