The neuronal architecture of the mushroom body provides a logic for associative learning

Yoshinori Aso, Daisuke Hattori, Yang Yu, Rebecca M. Johnston, Nirmala A. Iyer, Teri T.B. Ngo, Heather Dionne, L. F. Abbott, Richard Axel, Hiromu Tanimoto, Gerald M. Rubin

Research output: Contribution to journalArticle

285 Citations (Scopus)

Abstract

We identified the neurons comprising the Drosophila mushroom body (MB), an associative center in invertebrate brains, and provide a comprehensive map describing their potential connections. Each of the 21 MB output neuron (MBON) types elaborates segregated dendritic arbors along the parallel axons of ∼2000 Kenyon cells, forming 15 compartments that collectively tile the MB lobes. MBON axons project to five discrete neuropils outside of the MB and three MBON types form a feedforward network in the lobes. Each of the 20 dopaminergic neuron (DAN) types projects axons to one, or at most two, of the MBON compartments. Convergence of DAN axons on compartmentalized Kenyon cell-MBON synapses creates a highly ordered unit that can support learning to impose valence on sensory representations. The elucidation of the complement of neurons of the MB provides a comprehensive anatomical substrate from which one can infer a functional logic of associative olfactory learning and memory.

Original languageEnglish (US)
Pages (from-to)e04577
JournaleLife
Volume3
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Fingerprint

Mushroom Bodies
Neurons
Learning
Axons
Dopaminergic Neurons
Neuropil
Invertebrates
Synapses
Drosophila
Tile
Brain
Data storage equipment

Keywords

  • associative memory
  • D. melanogaster
  • dopamine
  • mushroom body
  • neuronal circuits
  • neuroscience
  • olfactory learning
  • plasticity

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Aso, Y., Hattori, D., Yu, Y., Johnston, R. M., Iyer, N. A., Ngo, T. T. B., ... Rubin, G. M. (2014). The neuronal architecture of the mushroom body provides a logic for associative learning. eLife, 3, e04577. https://doi.org/10.7554/eLife.04577

The neuronal architecture of the mushroom body provides a logic for associative learning. / Aso, Yoshinori; Hattori, Daisuke; Yu, Yang; Johnston, Rebecca M.; Iyer, Nirmala A.; Ngo, Teri T.B.; Dionne, Heather; Abbott, L. F.; Axel, Richard; Tanimoto, Hiromu; Rubin, Gerald M.

In: eLife, Vol. 3, 01.01.2014, p. e04577.

Research output: Contribution to journalArticle

Aso, Y, Hattori, D, Yu, Y, Johnston, RM, Iyer, NA, Ngo, TTB, Dionne, H, Abbott, LF, Axel, R, Tanimoto, H & Rubin, GM 2014, 'The neuronal architecture of the mushroom body provides a logic for associative learning', eLife, vol. 3, pp. e04577. https://doi.org/10.7554/eLife.04577
Aso, Yoshinori ; Hattori, Daisuke ; Yu, Yang ; Johnston, Rebecca M. ; Iyer, Nirmala A. ; Ngo, Teri T.B. ; Dionne, Heather ; Abbott, L. F. ; Axel, Richard ; Tanimoto, Hiromu ; Rubin, Gerald M. / The neuronal architecture of the mushroom body provides a logic for associative learning. In: eLife. 2014 ; Vol. 3. pp. e04577.
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