TY - JOUR
T1 - The onset time of rocuronium is slowed by esmolol and accelerated by ephedrine
AU - Szmuk, Peter
AU - Ezri, Tiberiu
AU - Chelly, Jacques E.
AU - Katz, Jeffrey
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2000
Y1 - 2000
N2 - Administration of ephedrine prior to rocuronium decreases the onset time of neuromuscular blockade from rocuronium by 26%. This effect was attributed to a increased cardiac output. If so, β adrenergic-blocking drugs, which decrease cardiac output, should prolong the onset time of rocuronium. In a double-blind study, 60 patients were randomly assigned to three groups (n = 20) to receive either 70 μg · kg-1 of ephedrine, 0.5 mg · kg-1 esmolol or placebo, 30 s before induction of anesthesia. Onset time of rocuronium was defined as the time from the end of its injection to disappearance of all four twitches of the train-of-four. The onset time of rocuronium was significantly shorter after ephedrine (22%) and longer after esmolol (26%), as compared to placebo. No differences were observed among the three groups with regard to heart rate, systolic, diastolic or mean blood pressure. We concluded that a dose of 0.5 mg · kg-1 of esmolol significantly prolongs the onset time of rocuronium with minimal hemodynamic changes.
AB - Administration of ephedrine prior to rocuronium decreases the onset time of neuromuscular blockade from rocuronium by 26%. This effect was attributed to a increased cardiac output. If so, β adrenergic-blocking drugs, which decrease cardiac output, should prolong the onset time of rocuronium. In a double-blind study, 60 patients were randomly assigned to three groups (n = 20) to receive either 70 μg · kg-1 of ephedrine, 0.5 mg · kg-1 esmolol or placebo, 30 s before induction of anesthesia. Onset time of rocuronium was defined as the time from the end of its injection to disappearance of all four twitches of the train-of-four. The onset time of rocuronium was significantly shorter after ephedrine (22%) and longer after esmolol (26%), as compared to placebo. No differences were observed among the three groups with regard to heart rate, systolic, diastolic or mean blood pressure. We concluded that a dose of 0.5 mg · kg-1 of esmolol significantly prolongs the onset time of rocuronium with minimal hemodynamic changes.
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U2 - 10.1097/00000539-200005000-00041
DO - 10.1097/00000539-200005000-00041
M3 - Article
C2 - 10781483
AN - SCOPUS:0034099131
SN - 0003-2999
VL - 90
SP - 1217
EP - 1219
JO - Anesthesia and analgesia
JF - Anesthesia and analgesia
IS - 5
ER -