The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress

Michael Lutter, Ichiro Sakata, Sherri Osborne-Lawrence, Sherry A. Rovinsky, Jason G. Anderson, Saendy Jung, Shari G Birnbaum, Masashi Yanagisawa, Joel K Elmquist, Eric J. Nestler, Jeffrey M Zigman

Research output: Contribution to journalArticle

370 Citations (Scopus)

Abstract

We found that increasing ghrelin levels, through subcutaneous injections or calorie restriction, produced anxiolytic- and antidepressant-like responses in the elevated plus maze and forced swim test. Moreover, chronic social defeat stress, a rodent model of depression, persistently increased ghrelin levels, whereas growth hormone secretagogue receptor (Ghsr) null mice showed increased deleterious effects of chronic defeat. Together, these findings demonstrate a previously unknown function for ghrelin in defending against depressive-like symptoms of chronic stress.

Original languageEnglish (US)
Pages (from-to)752-753
Number of pages2
JournalNature Neuroscience
Volume11
Issue number7
DOIs
StatePublished - Jul 2008

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Ghrelin
Hormones
Depression
Ghrelin Receptor
Anti-Anxiety Agents
Subcutaneous Injections
Antidepressive Agents
Rodentia

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Lutter, M., Sakata, I., Osborne-Lawrence, S., Rovinsky, S. A., Anderson, J. G., Jung, S., ... Zigman, J. M. (2008). The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress. Nature Neuroscience, 11(7), 752-753. https://doi.org/10.1038/nn.2139

The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress. / Lutter, Michael; Sakata, Ichiro; Osborne-Lawrence, Sherri; Rovinsky, Sherry A.; Anderson, Jason G.; Jung, Saendy; Birnbaum, Shari G; Yanagisawa, Masashi; Elmquist, Joel K; Nestler, Eric J.; Zigman, Jeffrey M.

In: Nature Neuroscience, Vol. 11, No. 7, 07.2008, p. 752-753.

Research output: Contribution to journalArticle

Lutter, M, Sakata, I, Osborne-Lawrence, S, Rovinsky, SA, Anderson, JG, Jung, S, Birnbaum, SG, Yanagisawa, M, Elmquist, JK, Nestler, EJ & Zigman, JM 2008, 'The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress', Nature Neuroscience, vol. 11, no. 7, pp. 752-753. https://doi.org/10.1038/nn.2139
Lutter M, Sakata I, Osborne-Lawrence S, Rovinsky SA, Anderson JG, Jung S et al. The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress. Nature Neuroscience. 2008 Jul;11(7):752-753. https://doi.org/10.1038/nn.2139
Lutter, Michael ; Sakata, Ichiro ; Osborne-Lawrence, Sherri ; Rovinsky, Sherry A. ; Anderson, Jason G. ; Jung, Saendy ; Birnbaum, Shari G ; Yanagisawa, Masashi ; Elmquist, Joel K ; Nestler, Eric J. ; Zigman, Jeffrey M. / The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress. In: Nature Neuroscience. 2008 ; Vol. 11, No. 7. pp. 752-753.
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