The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress

Michael Lutter; Ichiro Sakata; Sherri Osborne-Lawrence; Sherry A. Rovinsky; Jason G. Anderson; Saendy Jung; Shari G Birnbaum; Masashi Yanagisawa; Joel K Elmquist; Eric J. Nestler; Jeffrey M Zigman

doi:10.1038/nn.2139

The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress

Michael Lutter, Ichiro Sakata, Sherri Osborne-Lawrence, Sherry A. Rovinsky, Jason G. Anderson, Saendy Jung, Shari G Birnbaum, Masashi Yanagisawa, Joel K Elmquist, Eric J. Nestler, Jeffrey M Zigman

Research output: Contribution to journal › Article

378 Scopus citations

Abstract

We found that increasing ghrelin levels, through subcutaneous injections or calorie restriction, produced anxiolytic- and antidepressant-like responses in the elevated plus maze and forced swim test. Moreover, chronic social defeat stress, a rodent model of depression, persistently increased ghrelin levels, whereas growth hormone secretagogue receptor (Ghsr) null mice showed increased deleterious effects of chronic defeat. Together, these findings demonstrate a previously unknown function for ghrelin in defending against depressive-like symptoms of chronic stress.

Original language	English (US)
Pages (from-to)	752-753
Number of pages	2
Journal	Nature Neuroscience
Volume	11
Issue number	7
DOIs	https://doi.org/10.1038/nn.2139
State	Published - Jul 2008

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Lutter, M., Sakata, I., Osborne-Lawrence, S., Rovinsky, S. A., Anderson, J. G., Jung, S., Birnbaum, S. G., Yanagisawa, M., Elmquist, J. K., Nestler, E. J., & Zigman, J. M. (2008). The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress. Nature Neuroscience, 11(7), 752-753. https://doi.org/10.1038/nn.2139

The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress. / Lutter, Michael; Sakata, Ichiro; Osborne-Lawrence, Sherri; Rovinsky, Sherry A.; Anderson, Jason G.; Jung, Saendy; Birnbaum, Shari G ; Yanagisawa, Masashi ; Elmquist, Joel K; Nestler, Eric J.; Zigman, Jeffrey M.

In: Nature Neuroscience, Vol. 11, No. 7, 07.2008, p. 752-753.

Research output: Contribution to journal › Article

Lutter, Michael ; Sakata, Ichiro ; Osborne-Lawrence, Sherri ; Rovinsky, Sherry A. ; Anderson, Jason G. ; Jung, Saendy ; Birnbaum, Shari G ; Yanagisawa, Masashi ; Elmquist, Joel K ; Nestler, Eric J. ; Zigman, Jeffrey M. / The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress. In: Nature Neuroscience. 2008 ; Vol. 11, No. 7. pp. 752-753.

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