Abstract
We found that increasing ghrelin levels, through subcutaneous injections or calorie restriction, produced anxiolytic- and antidepressant-like responses in the elevated plus maze and forced swim test. Moreover, chronic social defeat stress, a rodent model of depression, persistently increased ghrelin levels, whereas growth hormone secretagogue receptor (Ghsr) null mice showed increased deleterious effects of chronic defeat. Together, these findings demonstrate a previously unknown function for ghrelin in defending against depressive-like symptoms of chronic stress.
Original language | English (US) |
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Pages (from-to) | 752-753 |
Number of pages | 2 |
Journal | Nature neuroscience |
Volume | 11 |
Issue number | 7 |
DOIs | |
State | Published - Jul 1 2008 |
ASJC Scopus subject areas
- Neuroscience(all)