Abstract
Ceftazidime (Tazicef) is a broad-spectrum cephalosporin antibiotic that may be useful as a topical agent in the treatment of otorrhea. To test the potential ototoxicity of the drug, 0.5 mL of a 10% solution of ceftazidime was introduced into the bullae of 22 chinchillas. The organ of Corti was normal in 20 temporal bones examined at 1 week after administration of the ceftazidime solution. Only 2 of 24 temporal bones examined after 4 weeks showed minor outer hair cell loss of the basal turn of the organ of Corti. Focal hemorrhage and occasional serous effusions were found in the middle ears of all animals after 1 week; these findings had mostly cleared after 4 weeks. Our results indicate that ceftazidime causes reversible middle ear inflammation, and may have some monor ototoxic potential under these experimental conditions.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 940-942 |
| Number of pages | 3 |
| Journal | Archives of Otolaryngology - Head and Neck Surgery |
| Volume | 115 |
| Issue number | 8 |
| State | Published - 1989 |
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ASJC Scopus subject areas
- Otorhinolaryngology
Cite this
The ototoxicity of ceftazidime in the chinchilla middle ear. / Brown, O. E.; Wright, C. G.; Edwards, L. B.; Meyerhoff, W. L.
In: Archives of Otolaryngology - Head and Neck Surgery, Vol. 115, No. 8, 1989, p. 940-942.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The ototoxicity of ceftazidime in the chinchilla middle ear
AU - Brown, O. E.
AU - Wright, C. G.
AU - Edwards, L. B.
AU - Meyerhoff, W. L.
PY - 1989
Y1 - 1989
N2 - Ceftazidime (Tazicef) is a broad-spectrum cephalosporin antibiotic that may be useful as a topical agent in the treatment of otorrhea. To test the potential ototoxicity of the drug, 0.5 mL of a 10% solution of ceftazidime was introduced into the bullae of 22 chinchillas. The organ of Corti was normal in 20 temporal bones examined at 1 week after administration of the ceftazidime solution. Only 2 of 24 temporal bones examined after 4 weeks showed minor outer hair cell loss of the basal turn of the organ of Corti. Focal hemorrhage and occasional serous effusions were found in the middle ears of all animals after 1 week; these findings had mostly cleared after 4 weeks. Our results indicate that ceftazidime causes reversible middle ear inflammation, and may have some monor ototoxic potential under these experimental conditions.
AB - Ceftazidime (Tazicef) is a broad-spectrum cephalosporin antibiotic that may be useful as a topical agent in the treatment of otorrhea. To test the potential ototoxicity of the drug, 0.5 mL of a 10% solution of ceftazidime was introduced into the bullae of 22 chinchillas. The organ of Corti was normal in 20 temporal bones examined at 1 week after administration of the ceftazidime solution. Only 2 of 24 temporal bones examined after 4 weeks showed minor outer hair cell loss of the basal turn of the organ of Corti. Focal hemorrhage and occasional serous effusions were found in the middle ears of all animals after 1 week; these findings had mostly cleared after 4 weeks. Our results indicate that ceftazidime causes reversible middle ear inflammation, and may have some monor ototoxic potential under these experimental conditions.
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UR - http://www.scopus.com/inward/citedby.url?scp=0024333594&partnerID=8YFLogxK
M3 - Article
C2 - 2665790
AN - SCOPUS:0024333594
VL - 115
SP - 940
EP - 942
JO - JAMA Otolaryngology - Head and Neck Surgery
JF - JAMA Otolaryngology - Head and Neck Surgery
SN - 2168-6181
IS - 8
ER -