The PARP Side of the Nucleus: Molecular Actions, Physiological Outcomes, and Clinical Targets

Raga Krishnakumar; W. Lee Kraus

doi:10.1016/j.molcel.2010.06.017

The PARP Side of the Nucleus: Molecular Actions, Physiological Outcomes, and Clinical Targets

Raga Krishnakumar, W. Lee Kraus

Research output: Contribution to journal › Review article › peer-review

706 Scopus citations

Abstract

The abundant nuclear enzyme PARP-1, a multifunctional regulator of chromatin structure, transcription, and genomic integrity, plays key roles in a wide variety of processes in the nucleus. Recent studies have begun to connect the molecular functions of PARP-1 to specific physiological and pathological outcomes, many of which can be altered by an expanding array of chemical inhibitors of PARP enzymatic activity.

Original language	English (US)
Pages (from-to)	8-24
Number of pages	17
Journal	Molecular cell
Volume	39
Issue number	1
DOIs	https://doi.org/10.1016/j.molcel.2010.06.017
State	Published - Jul 2010

ASJC Scopus subject areas

Molecular Biology
Cell Biology

Access to Document

10.1016/j.molcel.2010.06.017

Cite this

@article{7b3c4bf4a9874384b5f224af2cb5c716,

title = "The PARP Side of the Nucleus: Molecular Actions, Physiological Outcomes, and Clinical Targets",

abstract = "The abundant nuclear enzyme PARP-1, a multifunctional regulator of chromatin structure, transcription, and genomic integrity, plays key roles in a wide variety of processes in the nucleus. Recent studies have begun to connect the molecular functions of PARP-1 to specific physiological and pathological outcomes, many of which can be altered by an expanding array of chemical inhibitors of PARP enzymatic activity.",

author = "Raga Krishnakumar and Kraus, {W. Lee}",

note = "Funding Information: The authors would like to thank members of the Kraus and Lis labs for critical reading of this manuscript and Bryan Gibson for assistance with the structure figures. The research in the Kraus lab is supported by grants from the National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases (NIH/NIDDK).",

year = "2010",

month = jul,

doi = "10.1016/j.molcel.2010.06.017",

language = "English (US)",

volume = "39",

pages = "8--24",

journal = "Molecular cell",

issn = "1097-2765",

publisher = "Cell Press",

number = "1",

}

TY - JOUR

T1 - The PARP Side of the Nucleus

T2 - Molecular Actions, Physiological Outcomes, and Clinical Targets

AU - Krishnakumar, Raga

AU - Kraus, W. Lee

N1 - Funding Information: The authors would like to thank members of the Kraus and Lis labs for critical reading of this manuscript and Bryan Gibson for assistance with the structure figures. The research in the Kraus lab is supported by grants from the National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases (NIH/NIDDK).

PY - 2010/7

Y1 - 2010/7

N2 - The abundant nuclear enzyme PARP-1, a multifunctional regulator of chromatin structure, transcription, and genomic integrity, plays key roles in a wide variety of processes in the nucleus. Recent studies have begun to connect the molecular functions of PARP-1 to specific physiological and pathological outcomes, many of which can be altered by an expanding array of chemical inhibitors of PARP enzymatic activity.

AB - The abundant nuclear enzyme PARP-1, a multifunctional regulator of chromatin structure, transcription, and genomic integrity, plays key roles in a wide variety of processes in the nucleus. Recent studies have begun to connect the molecular functions of PARP-1 to specific physiological and pathological outcomes, many of which can be altered by an expanding array of chemical inhibitors of PARP enzymatic activity.

UR - http://www.scopus.com/inward/record.url?scp=77954274504&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77954274504&partnerID=8YFLogxK

U2 - 10.1016/j.molcel.2010.06.017

DO - 10.1016/j.molcel.2010.06.017

M3 - Review article

C2 - 20603072

AN - SCOPUS:77954274504

SN - 1097-2765

VL - 39

SP - 8

EP - 24

JO - Molecular cell

JF - Molecular cell

IS - 1

ER -

The PARP Side of the Nucleus: Molecular Actions, Physiological Outcomes, and Clinical Targets

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this