The PARP Side of the Nucleus: Molecular Actions, Physiological Outcomes, and Clinical Targets

Raga Krishnakumar, W. Lee Kraus

Research output: Contribution to journalReview article

514 Scopus citations


The abundant nuclear enzyme PARP-1, a multifunctional regulator of chromatin structure, transcription, and genomic integrity, plays key roles in a wide variety of processes in the nucleus. Recent studies have begun to connect the molecular functions of PARP-1 to specific physiological and pathological outcomes, many of which can be altered by an expanding array of chemical inhibitors of PARP enzymatic activity.

Original languageEnglish (US)
Pages (from-to)8-24
Number of pages17
JournalMolecular cell
Issue number1
StatePublished - Jul 1 2010


ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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