The PARP Side of the Nucleus: Molecular Actions, Physiological Outcomes, and Clinical Targets

Raga Krishnakumar, W. Lee Kraus

Research output: Contribution to journalArticle

498 Citations (Scopus)

Abstract

The abundant nuclear enzyme PARP-1, a multifunctional regulator of chromatin structure, transcription, and genomic integrity, plays key roles in a wide variety of processes in the nucleus. Recent studies have begun to connect the molecular functions of PARP-1 to specific physiological and pathological outcomes, many of which can be altered by an expanding array of chemical inhibitors of PARP enzymatic activity.

Original languageEnglish (US)
Pages (from-to)8-24
Number of pages17
JournalMolecular Cell
Volume39
Issue number1
DOIs
StatePublished - Jul 2010

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Chromatin
Enzymes
Poly(ADP-ribose) Polymerase Inhibitors

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

The PARP Side of the Nucleus : Molecular Actions, Physiological Outcomes, and Clinical Targets. / Krishnakumar, Raga; Kraus, W. Lee.

In: Molecular Cell, Vol. 39, No. 1, 07.2010, p. 8-24.

Research output: Contribution to journalArticle

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