The peptidyl-prolyl isomerase Pin1 regulates the stability of granulocyte-macrophage colony-stimulating factor mRNA in activated eosinophils

Zhong Jian Shen, Stephane Esnault, James S. Malter

Research output: Contribution to journalArticle

101 Scopus citations

Abstract

The infiltration, accumulation and degranulation of eosinophils in the lung represents a hallmark of active asthma. In vivo or in vitro eosinophil activation triggers the secretion of the antiapoptotic cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF). We now identify Pin1, a cis-trans isomerase, as an essential component of the ribonucleoprotein complex responsible for GM-CSF mRNA stabilization, cytokine secretion and the survival of activated eosinophils. Pin1 regulated the association of the AU-rich element -binding proteins AUF1 and hnRNP C with GM-CSF mRNA, accelerating or slowing decay, respectively. These data indicate Pin1 is a key mediator of GM-CSF production.

Original languageEnglish (US)
Pages (from-to)1280-1287
Number of pages8
JournalNature immunology
Volume6
Issue number12
DOIs
StatePublished - Dec 1 2005

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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