The potential for pre-, pro- and synbiotics in the management of infants at risk of cow's milk allergy or with cow's milk allergy: An exploration of the rationale, available evidence and remaining questions

Adam Fox, J. Andrew Bird, Alessandro Fiocchi, Jan Knol, Rosan Meyer, Seppo Salminen, Gong Sitang, Hania Szajewska, Nikolaos Papadopoulos

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Cow's milk allergy is one of the most commonly reported childhood food allergies, with increasing incidence, persistence and severity in many countries across the world. The World Allergy Organization Special Committee on Food Allergy has identified cow's milk allergy as an area in need of a rationale-based approach in order to make progress against what it considered an onerous problem, with worldwide public health impact. There is growing interest in the potential role of the gut microbiota in the early programming and development of immune responses and allergy. This discussion paper considers the rationale and available evidence for modulation of the gut microbiota and for the use of synbiotics in the management of infants at risk of, or living with cow's milk allergy and summarizes remaining research questions that need to be answered for the development of evidence-based recommendations.

Original languageEnglish (US)
Article number100034
JournalWorld Allergy Organization Journal
Volume12
Issue number5
DOIs
StatePublished - 2019

Keywords

  • Allergy
  • Anaphylaxis
  • Bifidobacteria
  • Cow's milk allergy
  • Dysbiosis
  • IgE
  • Lactobacilli
  • Microbiota
  • Prebiotic
  • Probiotic
  • Synbiotic
  • World Allergy Organization

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pulmonary and Respiratory Medicine

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