The prevalence of deep venous thrombosis after total hip arthroplasty with hypotensive epidural anesthesia

J. R. Lieberman, M. M. Huo, J. Hanway, E. A. Salvati, T. P. Sculco, N. E. Sharrock

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

A prospective, randomized trial was done to evaluate the prevalence of deep venous thrombosis following primary unilateral or bilateral total hip arthroplasty with use of hypotensive epidural anesthesia, external pneumatic- compression boots, and aspirin (Group I) and with use of hypotensive epidural anesthesia and aspirin (Group II). All operations were performed by two of us (E. A. S. and T. P. S.) through a posterolateral approach. Two hundred and thirty-one patients who were more than thirty-nine years old and who had a total of 250 primary total hip arthroplasties were included in the study. There were 113 patients (124 hips) in Group I and 118 patients (126 hips) in Group II. All patients had venography on the sixth, seventh, or eighth postoperative day. Group I had no proximal thrombi, seven distal thrombi (6 per cent), and one late pulmonary embolus (1 per cent). Group II had one proximal thrombus (popliteal) (1 per cent), eight distal thrombi (6 per cent), and one late pulmonary embolus (1 per cent). The difference was not significant (p = 0.65). However, a significant difference may have been noted if the study population had been larger. The combination of hypotensive epidural anesthesia and aspirin is effective prophylaxis against deep venous thrombosis in patients who have a primary total hip arthroplasty. The extremely low rate of deep venous thrombosis in the present study may be attributed to the use of hypotensive epidural anesthesia and the associated decrease in blood loss and transfusion requirements. Hypotensive epidural anesthesia is relatively safe, even in elderly patients who have hypertension, but since it can be associated with potentially serious problems, it requires additional expertise in anesthesia and monitoring that may not be available in all centers.

Original languageEnglish (US)
Pages (from-to)341-348
Number of pages8
JournalJournal of Bone and Joint Surgery - Series A
Volume76
Issue number3
StatePublished - 1994

Fingerprint

Epidural Anesthesia
Venous Thrombosis
Arthroplasty
Hip
Thrombosis
Aspirin
Embolism
Lung
Phlebography
Blood Transfusion
Anesthesia
Hypertension
Population

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

The prevalence of deep venous thrombosis after total hip arthroplasty with hypotensive epidural anesthesia. / Lieberman, J. R.; Huo, M. M.; Hanway, J.; Salvati, E. A.; Sculco, T. P.; Sharrock, N. E.

In: Journal of Bone and Joint Surgery - Series A, Vol. 76, No. 3, 1994, p. 341-348.

Research output: Contribution to journalArticle

Lieberman, J. R. ; Huo, M. M. ; Hanway, J. ; Salvati, E. A. ; Sculco, T. P. ; Sharrock, N. E. / The prevalence of deep venous thrombosis after total hip arthroplasty with hypotensive epidural anesthesia. In: Journal of Bone and Joint Surgery - Series A. 1994 ; Vol. 76, No. 3. pp. 341-348.
@article{d4ecbeb2c3204d4fb041d1bac424af75,
title = "The prevalence of deep venous thrombosis after total hip arthroplasty with hypotensive epidural anesthesia",
abstract = "A prospective, randomized trial was done to evaluate the prevalence of deep venous thrombosis following primary unilateral or bilateral total hip arthroplasty with use of hypotensive epidural anesthesia, external pneumatic- compression boots, and aspirin (Group I) and with use of hypotensive epidural anesthesia and aspirin (Group II). All operations were performed by two of us (E. A. S. and T. P. S.) through a posterolateral approach. Two hundred and thirty-one patients who were more than thirty-nine years old and who had a total of 250 primary total hip arthroplasties were included in the study. There were 113 patients (124 hips) in Group I and 118 patients (126 hips) in Group II. All patients had venography on the sixth, seventh, or eighth postoperative day. Group I had no proximal thrombi, seven distal thrombi (6 per cent), and one late pulmonary embolus (1 per cent). Group II had one proximal thrombus (popliteal) (1 per cent), eight distal thrombi (6 per cent), and one late pulmonary embolus (1 per cent). The difference was not significant (p = 0.65). However, a significant difference may have been noted if the study population had been larger. The combination of hypotensive epidural anesthesia and aspirin is effective prophylaxis against deep venous thrombosis in patients who have a primary total hip arthroplasty. The extremely low rate of deep venous thrombosis in the present study may be attributed to the use of hypotensive epidural anesthesia and the associated decrease in blood loss and transfusion requirements. Hypotensive epidural anesthesia is relatively safe, even in elderly patients who have hypertension, but since it can be associated with potentially serious problems, it requires additional expertise in anesthesia and monitoring that may not be available in all centers.",
author = "Lieberman, {J. R.} and Huo, {M. M.} and J. Hanway and Salvati, {E. A.} and Sculco, {T. P.} and Sharrock, {N. E.}",
year = "1994",
language = "English (US)",
volume = "76",
pages = "341--348",
journal = "Journal of Bone and Joint Surgery - American Volume",
issn = "0021-9355",
publisher = "Journal of Bone and Joint Surgery Inc.",
number = "3",

}

TY - JOUR

T1 - The prevalence of deep venous thrombosis after total hip arthroplasty with hypotensive epidural anesthesia

AU - Lieberman, J. R.

AU - Huo, M. M.

AU - Hanway, J.

AU - Salvati, E. A.

AU - Sculco, T. P.

AU - Sharrock, N. E.

PY - 1994

Y1 - 1994

N2 - A prospective, randomized trial was done to evaluate the prevalence of deep venous thrombosis following primary unilateral or bilateral total hip arthroplasty with use of hypotensive epidural anesthesia, external pneumatic- compression boots, and aspirin (Group I) and with use of hypotensive epidural anesthesia and aspirin (Group II). All operations were performed by two of us (E. A. S. and T. P. S.) through a posterolateral approach. Two hundred and thirty-one patients who were more than thirty-nine years old and who had a total of 250 primary total hip arthroplasties were included in the study. There were 113 patients (124 hips) in Group I and 118 patients (126 hips) in Group II. All patients had venography on the sixth, seventh, or eighth postoperative day. Group I had no proximal thrombi, seven distal thrombi (6 per cent), and one late pulmonary embolus (1 per cent). Group II had one proximal thrombus (popliteal) (1 per cent), eight distal thrombi (6 per cent), and one late pulmonary embolus (1 per cent). The difference was not significant (p = 0.65). However, a significant difference may have been noted if the study population had been larger. The combination of hypotensive epidural anesthesia and aspirin is effective prophylaxis against deep venous thrombosis in patients who have a primary total hip arthroplasty. The extremely low rate of deep venous thrombosis in the present study may be attributed to the use of hypotensive epidural anesthesia and the associated decrease in blood loss and transfusion requirements. Hypotensive epidural anesthesia is relatively safe, even in elderly patients who have hypertension, but since it can be associated with potentially serious problems, it requires additional expertise in anesthesia and monitoring that may not be available in all centers.

AB - A prospective, randomized trial was done to evaluate the prevalence of deep venous thrombosis following primary unilateral or bilateral total hip arthroplasty with use of hypotensive epidural anesthesia, external pneumatic- compression boots, and aspirin (Group I) and with use of hypotensive epidural anesthesia and aspirin (Group II). All operations were performed by two of us (E. A. S. and T. P. S.) through a posterolateral approach. Two hundred and thirty-one patients who were more than thirty-nine years old and who had a total of 250 primary total hip arthroplasties were included in the study. There were 113 patients (124 hips) in Group I and 118 patients (126 hips) in Group II. All patients had venography on the sixth, seventh, or eighth postoperative day. Group I had no proximal thrombi, seven distal thrombi (6 per cent), and one late pulmonary embolus (1 per cent). Group II had one proximal thrombus (popliteal) (1 per cent), eight distal thrombi (6 per cent), and one late pulmonary embolus (1 per cent). The difference was not significant (p = 0.65). However, a significant difference may have been noted if the study population had been larger. The combination of hypotensive epidural anesthesia and aspirin is effective prophylaxis against deep venous thrombosis in patients who have a primary total hip arthroplasty. The extremely low rate of deep venous thrombosis in the present study may be attributed to the use of hypotensive epidural anesthesia and the associated decrease in blood loss and transfusion requirements. Hypotensive epidural anesthesia is relatively safe, even in elderly patients who have hypertension, but since it can be associated with potentially serious problems, it requires additional expertise in anesthesia and monitoring that may not be available in all centers.

UR - http://www.scopus.com/inward/record.url?scp=0028224415&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028224415&partnerID=8YFLogxK

M3 - Article

VL - 76

SP - 341

EP - 348

JO - Journal of Bone and Joint Surgery - American Volume

JF - Journal of Bone and Joint Surgery - American Volume

SN - 0021-9355

IS - 3

ER -