The primary sequence of murine caveolin reveals a conserved consensus site for phosphorylation by protein kinase C

ZhaoLan Tang, Philipp E. Scherer, Michael P. Lisanti

Research output: Contribution to journalArticlepeer-review

55 Scopus citations

Abstract

We report here the cloning of the murine cDNA encoding caveolin, a known v-Src substrate and caveolar marker protein. Interestingly, analysis of the murine cDNA and comparison with caveolin from other species reveals a previously unrecognized consensus site for protein kinase C (PKC) phosphorylation. This finding could have important implications as (i) both the morphology and function of caveolae are dramatically affected by PKC activators; and (ii) PKC, is concentrated in isolated caveolin-rich membrane domains. In addition, this first step should facilitate the use of the mouse as a genetic system for elucidating the role of caveolin in caveolar functioning.

Original languageEnglish (US)
Pages (from-to)299-300
Number of pages2
JournalGene
Volume147
Issue number2
DOIs
StatePublished - Sep 30 1994

Keywords

  • Caveolae
  • cell transformation
  • potocytosis
  • signalling
  • v-Src substrate

ASJC Scopus subject areas

  • Genetics

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