The prognostic significance of the triple negative phenotype in endometrial cancer

Rajul Kothari, Carl Morrison, Debra Richardson, Shelly Seward, David O'Malley, Larry Copeland, Jeffrey Fowler, David E. Cohn

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective. To determine if the triple negative phenotype (TNP) has prognostic significance in endometrial cancer with respect to various surgicopathologic outcomes and survival. Methods. A tissue microarray was constructed of 396 endometrial cancers from patients who underwent surgical staging at the Ohio State University Medical Center. Immunohistochemistry was used to test for estrogen receptor, progesterone receptor, and HER2 expression. Fluorescent in-situ hybridization (FISH) was also used to test for HER2 amplification. TNP negative patients served as controls. Pearson's chi-square was used to evaluate the association of the TNP with variables associated with a poor prognosis. Cox proportional hazards model was used to perform univariate and multivariate analyses. Progression free survival (PFS) and overall survival (OS) were analyzed with Kaplan-Meier curves, and the log rank test was used to compare the groups. Results. Twenty-seven percent of patients had the TNP. The TNP was associated with lymph node metastasis, myometrial invasion (>50%), high grade disease, nonendometrioid histology, and advanced staged disease (p<0.023 for lymph node metastasis and p<0.0001 for all others). The TNP was associated with a significantly worse survival, including a decreased PFS (p=0.009) and OS (p=0.01), but not in a fashion independent of other prognostic variables. Conclusions. The TNP is associated with advanced stage, high grade, and high risk histology, as well as poor survival. Continued investigation of the exploitation of this phenotype with targeted therapies is necessary.

Original languageEnglish (US)
Pages (from-to)172-175
Number of pages4
JournalGynecologic Oncology
Volume118
Issue number2
DOIs
StatePublished - Aug 1 2010

Fingerprint

Endometrial Neoplasms
Phenotype
Survival
Disease-Free Survival
Histology
Lymph Nodes
Neoplasm Metastasis
Progesterone Receptors
Fluorescence In Situ Hybridization
Proportional Hazards Models
Estrogen Receptors
Multivariate Analysis
Immunohistochemistry

Keywords

  • Endometrial cancer
  • Prognosis
  • Triple negative phenotype

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Oncology

Cite this

Kothari, R., Morrison, C., Richardson, D., Seward, S., O'Malley, D., Copeland, L., ... Cohn, D. E. (2010). The prognostic significance of the triple negative phenotype in endometrial cancer. Gynecologic Oncology, 118(2), 172-175. https://doi.org/10.1016/j.ygyno.2010.04.015

The prognostic significance of the triple negative phenotype in endometrial cancer. / Kothari, Rajul; Morrison, Carl; Richardson, Debra; Seward, Shelly; O'Malley, David; Copeland, Larry; Fowler, Jeffrey; Cohn, David E.

In: Gynecologic Oncology, Vol. 118, No. 2, 01.08.2010, p. 172-175.

Research output: Contribution to journalArticle

Kothari, R, Morrison, C, Richardson, D, Seward, S, O'Malley, D, Copeland, L, Fowler, J & Cohn, DE 2010, 'The prognostic significance of the triple negative phenotype in endometrial cancer', Gynecologic Oncology, vol. 118, no. 2, pp. 172-175. https://doi.org/10.1016/j.ygyno.2010.04.015
Kothari, Rajul ; Morrison, Carl ; Richardson, Debra ; Seward, Shelly ; O'Malley, David ; Copeland, Larry ; Fowler, Jeffrey ; Cohn, David E. / The prognostic significance of the triple negative phenotype in endometrial cancer. In: Gynecologic Oncology. 2010 ; Vol. 118, No. 2. pp. 172-175.
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AU - Fowler, Jeffrey

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N2 - Objective. To determine if the triple negative phenotype (TNP) has prognostic significance in endometrial cancer with respect to various surgicopathologic outcomes and survival. Methods. A tissue microarray was constructed of 396 endometrial cancers from patients who underwent surgical staging at the Ohio State University Medical Center. Immunohistochemistry was used to test for estrogen receptor, progesterone receptor, and HER2 expression. Fluorescent in-situ hybridization (FISH) was also used to test for HER2 amplification. TNP negative patients served as controls. Pearson's chi-square was used to evaluate the association of the TNP with variables associated with a poor prognosis. Cox proportional hazards model was used to perform univariate and multivariate analyses. Progression free survival (PFS) and overall survival (OS) were analyzed with Kaplan-Meier curves, and the log rank test was used to compare the groups. Results. Twenty-seven percent of patients had the TNP. The TNP was associated with lymph node metastasis, myometrial invasion (>50%), high grade disease, nonendometrioid histology, and advanced staged disease (p<0.023 for lymph node metastasis and p<0.0001 for all others). The TNP was associated with a significantly worse survival, including a decreased PFS (p=0.009) and OS (p=0.01), but not in a fashion independent of other prognostic variables. Conclusions. The TNP is associated with advanced stage, high grade, and high risk histology, as well as poor survival. Continued investigation of the exploitation of this phenotype with targeted therapies is necessary.

AB - Objective. To determine if the triple negative phenotype (TNP) has prognostic significance in endometrial cancer with respect to various surgicopathologic outcomes and survival. Methods. A tissue microarray was constructed of 396 endometrial cancers from patients who underwent surgical staging at the Ohio State University Medical Center. Immunohistochemistry was used to test for estrogen receptor, progesterone receptor, and HER2 expression. Fluorescent in-situ hybridization (FISH) was also used to test for HER2 amplification. TNP negative patients served as controls. Pearson's chi-square was used to evaluate the association of the TNP with variables associated with a poor prognosis. Cox proportional hazards model was used to perform univariate and multivariate analyses. Progression free survival (PFS) and overall survival (OS) were analyzed with Kaplan-Meier curves, and the log rank test was used to compare the groups. Results. Twenty-seven percent of patients had the TNP. The TNP was associated with lymph node metastasis, myometrial invasion (>50%), high grade disease, nonendometrioid histology, and advanced staged disease (p<0.023 for lymph node metastasis and p<0.0001 for all others). The TNP was associated with a significantly worse survival, including a decreased PFS (p=0.009) and OS (p=0.01), but not in a fashion independent of other prognostic variables. Conclusions. The TNP is associated with advanced stage, high grade, and high risk histology, as well as poor survival. Continued investigation of the exploitation of this phenotype with targeted therapies is necessary.

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