The promise of organ and tissue preservation to transform medicine

Sebastian Giwa, Jedediah K. Lewis, Luis Alvarez, Robert Langer, Alvin E. Roth, George M. Church, James F. Markmann, David H. Sachs, Anil Chandraker, Jason A. Wertheim, Martine Rothblatt, Edward S. Boyden, Elling Eidbo, W. P.Andrew Lee, Bohdan Pomahac, Gerald Brandacher, David M. Weinstock, Gloria Elliott, David Nelson, Jason P. AckerKorkut Uygun, Boris Schmalz, Brad P. Weegman, Alessandro Tocchio, Greg M. Fahy, Kenneth B. Storey, Boris Rubinsky, John Bischof, Janet A.W. Elliott, Teresa K. Woodruff, G. John Morris, Utkan Demirci, Kelvin G.M. Brockbank, Erik J. Woods, Robert N. Ben, John G. Baust, Dayong Gao, Barry Fuller, Yoed Rabin, David C. Kravitz, Michael J. Taylor, Mehmet Toner

Research output: Contribution to journalReview article

103 Scopus citations

Abstract

The ability to replace organs and tissues on demand could save or improve millions of lives each year globally and create public health benefits on par with curing cancer. Unmet needs for organ and tissue preservation place enormous logistical limitations on transplantation, regenerative medicine, drug discovery, and a variety of rapidly advancing areas spanning biomedicine. A growing coalition of researchers, clinicians, advocacy organizations, academic institutions, and other stakeholders has assembled to address the unmet need for preservation advances, outlining remaining challenges and identifying areas of underinvestment and untapped opportunities. Meanwhile, recent discoveries provide proofs of principle for breakthroughs in a family of research areas surrounding biopreservation. These developments indicate that a new paradigm, integrating multiple existing preservation approaches and new technologies that have flourished in the past 10 years, could transform preservation research. Capitalizing on these opportunities will require engagement across many research areas and stakeholder groups. A coordinated effort is needed to expedite preservation advances that can transform several areas of medicine and medical science.

Original languageEnglish (US)
Pages (from-to)530-542
Number of pages13
JournalNature biotechnology
Volume35
Issue number6
DOIs
StatePublished - Jun 7 2017
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology
  • Molecular Medicine
  • Biomedical Engineering

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    Giwa, S., Lewis, J. K., Alvarez, L., Langer, R., Roth, A. E., Church, G. M., Markmann, J. F., Sachs, D. H., Chandraker, A., Wertheim, J. A., Rothblatt, M., Boyden, E. S., Eidbo, E., Lee, W. P. A., Pomahac, B., Brandacher, G., Weinstock, D. M., Elliott, G., Nelson, D., ... Toner, M. (2017). The promise of organ and tissue preservation to transform medicine. Nature biotechnology, 35(6), 530-542. https://doi.org/10.1038/nbt.3889