The relationship of maternal glycemia to childhood obesity and metabolic dysfunction

on behalf of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units (MFMU) Network

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: To determine the association of maternal glycemia with childhood obesity and metabolic dysfunction. Study design: Secondary analysis of follow-up data 5–10 years after a mild gestational diabetes mellitus (GDM) treatment trial. The relationship between maternal oral glucose tolerance testing (OGTT) at 24–31-week gestation and body mass index (BMI), fasting glucose, insulin, and anthropometric measurements (sum of skinfolds, subscapular/triceps ratio, and waist circumference) in the offspring of untreated mild GDM and non-GDM (abnormal 50-g screen/normal OGTT) women was assessed. Multivariable regression modeling controlling for maternal and neonatal characteristics was employed. Results: A cohort of 236 untreated mild GDM and 480 non-GDM offspring were analyzed. In the combined cohort, significant correlations existed between fasting, 1, 2, and 3 h maternal glucose and subscapular/triceps ratio (all p <.04) and in all OGTT values other than the 2-hour value for homeostatic model assessment-estimated insulin resistance (HOMA-IR) (all p <.04) and sum of skinfold measurements (all p <.03). No correlation was found between OGTT values and childhood BMI Z-score. Multivariable regression modeling showed that OGTT values were associated with only sum of skinfolds and subscapular/triceps ratio and not with childhood BMI Z-score. Hispanic ethnicity and prepregnancy maternal BMI were most consistently related to childhood BMI Z-score and HOMA-IR, and Hispanic ethnicity with fasting glucose. Conclusions: Among women with untreated mild GDM and those without GDM, maternal glycemia is associated with childhood anthropometric measures of obesity but not childhood BMI, fasting glucose, or insulin resistance. Hispanic ethnicity, maternal BMI, and gestational weight gain were consistently related to childhood BMI.

Original languageEnglish (US)
JournalJournal of Maternal-Fetal and Neonatal Medicine
DOIs
StateAccepted/In press - Jan 1 2018

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Pediatric Obesity
Body Mass Index
Gestational Diabetes
Mothers
Glucose Tolerance Test
Fasting
Hispanic Americans
Insulin Resistance
Glucose
Diabetes Mellitus
Waist Circumference
Weight Gain
Insulin
Pregnancy

Keywords

  • Childhood obesity
  • fetal programing
  • maternal diabetes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

on behalf of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units (MFMU) Network (Accepted/In press). The relationship of maternal glycemia to childhood obesity and metabolic dysfunction Journal of Maternal-Fetal and Neonatal Medicine. https://doi.org/10.1080/14767058.2018.1484094

The relationship of maternal glycemia to childhood obesity and metabolic dysfunction . / on behalf of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units (MFMU) Network.

In: Journal of Maternal-Fetal and Neonatal Medicine, 01.01.2018.

Research output: Contribution to journalArticle

on behalf of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units (MFMU) Network 2018, 'The relationship of maternal glycemia to childhood obesity and metabolic dysfunction ', Journal of Maternal-Fetal and Neonatal Medicine. https://doi.org/10.1080/14767058.2018.1484094
on behalf of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units (MFMU) Network. The relationship of maternal glycemia to childhood obesity and metabolic dysfunction Journal of Maternal-Fetal and Neonatal Medicine. 2018 Jan 1. https://doi.org/10.1080/14767058.2018.1484094
on behalf of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units (MFMU) Network. / The relationship of maternal glycemia to childhood obesity and metabolic dysfunction In: Journal of Maternal-Fetal and Neonatal Medicine. 2018.
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AU - on behalf of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units (MFMU) Network

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AU - Mele, Lisa

AU - Varner, Michael W.

AU - Casey, Brian M.

AU - Reddy, Uma M.

AU - Wapner, Ronald J.

AU - Rouse, Dwight J.

AU - Tita, Alan T.N.

AU - Thorp, John M.

AU - Chien, Edward K.

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N2 - Objective: To determine the association of maternal glycemia with childhood obesity and metabolic dysfunction. Study design: Secondary analysis of follow-up data 5–10 years after a mild gestational diabetes mellitus (GDM) treatment trial. The relationship between maternal oral glucose tolerance testing (OGTT) at 24–31-week gestation and body mass index (BMI), fasting glucose, insulin, and anthropometric measurements (sum of skinfolds, subscapular/triceps ratio, and waist circumference) in the offspring of untreated mild GDM and non-GDM (abnormal 50-g screen/normal OGTT) women was assessed. Multivariable regression modeling controlling for maternal and neonatal characteristics was employed. Results: A cohort of 236 untreated mild GDM and 480 non-GDM offspring were analyzed. In the combined cohort, significant correlations existed between fasting, 1, 2, and 3 h maternal glucose and subscapular/triceps ratio (all p <.04) and in all OGTT values other than the 2-hour value for homeostatic model assessment-estimated insulin resistance (HOMA-IR) (all p <.04) and sum of skinfold measurements (all p <.03). No correlation was found between OGTT values and childhood BMI Z-score. Multivariable regression modeling showed that OGTT values were associated with only sum of skinfolds and subscapular/triceps ratio and not with childhood BMI Z-score. Hispanic ethnicity and prepregnancy maternal BMI were most consistently related to childhood BMI Z-score and HOMA-IR, and Hispanic ethnicity with fasting glucose. Conclusions: Among women with untreated mild GDM and those without GDM, maternal glycemia is associated with childhood anthropometric measures of obesity but not childhood BMI, fasting glucose, or insulin resistance. Hispanic ethnicity, maternal BMI, and gestational weight gain were consistently related to childhood BMI.

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KW - fetal programing

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