Abstract
Treatment of hepatitis C with interferon therapy produced some cures early on, but was associated with significant side effects. Because of further advances in the molecular understanding of hepatitis C, by 2014 effective treatments became available that far surpassed all prior interferon-based regimens in efficacy, tolerability, and safety. This led to rapid transformation of a hard-to-treat disease to simple, safe, and effective treatment offered to anyone. This article focuses on hepatitis C epidemiology; the clinical impact and consequences; discussion of past hepatitis C treatments; and a review of current recommendations for screening, diagnosis, and treatment of this ubiquitous virus.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 43-55 |
| Number of pages | 13 |
| Journal | Medical Clinics of North America |
| Volume | 103 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2019 |
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Keywords
- Direct-acting antivirals
- Hepatitis C virus
- Polymerase inhibitors
- Protease inhibitors
- Sustained viral response
ASJC Scopus subject areas
- Medicine(all)
Cite this
The Revolution in Treatment of Hepatitis C. / Mayberry, Jordan; Lee, William M.
In: Medical Clinics of North America, Vol. 103, No. 1, 01.01.2019, p. 43-55.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - The Revolution in Treatment of Hepatitis C
AU - Mayberry, Jordan
AU - Lee, William M
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Treatment of hepatitis C with interferon therapy produced some cures early on, but was associated with significant side effects. Because of further advances in the molecular understanding of hepatitis C, by 2014 effective treatments became available that far surpassed all prior interferon-based regimens in efficacy, tolerability, and safety. This led to rapid transformation of a hard-to-treat disease to simple, safe, and effective treatment offered to anyone. This article focuses on hepatitis C epidemiology; the clinical impact and consequences; discussion of past hepatitis C treatments; and a review of current recommendations for screening, diagnosis, and treatment of this ubiquitous virus.
AB - Treatment of hepatitis C with interferon therapy produced some cures early on, but was associated with significant side effects. Because of further advances in the molecular understanding of hepatitis C, by 2014 effective treatments became available that far surpassed all prior interferon-based regimens in efficacy, tolerability, and safety. This led to rapid transformation of a hard-to-treat disease to simple, safe, and effective treatment offered to anyone. This article focuses on hepatitis C epidemiology; the clinical impact and consequences; discussion of past hepatitis C treatments; and a review of current recommendations for screening, diagnosis, and treatment of this ubiquitous virus.
KW - Direct-acting antivirals
KW - Hepatitis C virus
KW - Polymerase inhibitors
KW - Protease inhibitors
KW - Sustained viral response
UR - http://www.scopus.com/inward/record.url?scp=85056792880&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85056792880&partnerID=8YFLogxK
U2 - 10.1016/j.mcna.2018.08.007
DO - 10.1016/j.mcna.2018.08.007
M3 - Review article
C2 - 30466675
AN - SCOPUS:85056792880
VL - 103
SP - 43
EP - 55
JO - Medical Clinics of North America
JF - Medical Clinics of North America
SN - 0025-7125
IS - 1
ER -