The role of astrocytes in autoimmune disease of the central nervous system

Olaf Stüve, Scott S. Zamvil

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Astrocytes are the most abundant glial cell population in the central nervous system (CNS). In the healthy brain and spinal cord, the major function of astrocytes includes the formation and maintenance of the blood brain barrier (BBB), and the supply of structural support and nourishment to neurons. This article will discuss the role of astrocytes in multiple sclerosis (MS) and other inflammatory autoimmune diseases of the CNS. We will address the capacity of astrocytes to serve as immunocompetent cells, their role in major histocompatibility complex (MHC) class II restricted antigen (Ag) presentation, and their ability to express costimulatory molecules. We will also discuss astrocytes as the major CNS producers of several chemokines and cytokines, and their relevance to neurological disease.

Original languageEnglish (US)
Title of host publicationExperimental Models of Multiple Sclerosis
PublisherSpringer US
Pages85-108
Number of pages24
ISBN (Print)9780387255187, 0387255176, 9780387255170
DOIs
StatePublished - 2005

Fingerprint

Autoimmune Diseases of the Nervous System
Astrocytes
Central Nervous System
Histocompatibility Antigens Class II
Antigen Presentation
Major Histocompatibility Complex
Blood-Brain Barrier
Chemokines
Neuroglia
Multiple Sclerosis
Spinal Cord
Maintenance
Cytokines
Neurons
Brain
Population

Keywords

  • antigen presentation
  • astrocytes
  • co-stimulatory molecules
  • major histocompatibility complex

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

Cite this

Stüve, O., & Zamvil, S. S. (2005). The role of astrocytes in autoimmune disease of the central nervous system. In Experimental Models of Multiple Sclerosis (pp. 85-108). Springer US. https://doi.org/10.1007/0-387-25518-4_6

The role of astrocytes in autoimmune disease of the central nervous system. / Stüve, Olaf; Zamvil, Scott S.

Experimental Models of Multiple Sclerosis. Springer US, 2005. p. 85-108.

Research output: Chapter in Book/Report/Conference proceedingChapter

Stüve, O & Zamvil, SS 2005, The role of astrocytes in autoimmune disease of the central nervous system. in Experimental Models of Multiple Sclerosis. Springer US, pp. 85-108. https://doi.org/10.1007/0-387-25518-4_6
Stüve O, Zamvil SS. The role of astrocytes in autoimmune disease of the central nervous system. In Experimental Models of Multiple Sclerosis. Springer US. 2005. p. 85-108 https://doi.org/10.1007/0-387-25518-4_6
Stüve, Olaf ; Zamvil, Scott S. / The role of astrocytes in autoimmune disease of the central nervous system. Experimental Models of Multiple Sclerosis. Springer US, 2005. pp. 85-108
@inbook{7585aec544924f25833e65e8934a3326,
title = "The role of astrocytes in autoimmune disease of the central nervous system",
abstract = "Astrocytes are the most abundant glial cell population in the central nervous system (CNS). In the healthy brain and spinal cord, the major function of astrocytes includes the formation and maintenance of the blood brain barrier (BBB), and the supply of structural support and nourishment to neurons. This article will discuss the role of astrocytes in multiple sclerosis (MS) and other inflammatory autoimmune diseases of the CNS. We will address the capacity of astrocytes to serve as immunocompetent cells, their role in major histocompatibility complex (MHC) class II restricted antigen (Ag) presentation, and their ability to express costimulatory molecules. We will also discuss astrocytes as the major CNS producers of several chemokines and cytokines, and their relevance to neurological disease.",
keywords = "antigen presentation, astrocytes, co-stimulatory molecules, major histocompatibility complex",
author = "Olaf St{\"u}ve and Zamvil, {Scott S.}",
year = "2005",
doi = "10.1007/0-387-25518-4_6",
language = "English (US)",
isbn = "9780387255187",
pages = "85--108",
booktitle = "Experimental Models of Multiple Sclerosis",
publisher = "Springer US",

}

TY - CHAP

T1 - The role of astrocytes in autoimmune disease of the central nervous system

AU - Stüve, Olaf

AU - Zamvil, Scott S.

PY - 2005

Y1 - 2005

N2 - Astrocytes are the most abundant glial cell population in the central nervous system (CNS). In the healthy brain and spinal cord, the major function of astrocytes includes the formation and maintenance of the blood brain barrier (BBB), and the supply of structural support and nourishment to neurons. This article will discuss the role of astrocytes in multiple sclerosis (MS) and other inflammatory autoimmune diseases of the CNS. We will address the capacity of astrocytes to serve as immunocompetent cells, their role in major histocompatibility complex (MHC) class II restricted antigen (Ag) presentation, and their ability to express costimulatory molecules. We will also discuss astrocytes as the major CNS producers of several chemokines and cytokines, and their relevance to neurological disease.

AB - Astrocytes are the most abundant glial cell population in the central nervous system (CNS). In the healthy brain and spinal cord, the major function of astrocytes includes the formation and maintenance of the blood brain barrier (BBB), and the supply of structural support and nourishment to neurons. This article will discuss the role of astrocytes in multiple sclerosis (MS) and other inflammatory autoimmune diseases of the CNS. We will address the capacity of astrocytes to serve as immunocompetent cells, their role in major histocompatibility complex (MHC) class II restricted antigen (Ag) presentation, and their ability to express costimulatory molecules. We will also discuss astrocytes as the major CNS producers of several chemokines and cytokines, and their relevance to neurological disease.

KW - antigen presentation

KW - astrocytes

KW - co-stimulatory molecules

KW - major histocompatibility complex

UR - http://www.scopus.com/inward/record.url?scp=84919849439&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84919849439&partnerID=8YFLogxK

U2 - 10.1007/0-387-25518-4_6

DO - 10.1007/0-387-25518-4_6

M3 - Chapter

AN - SCOPUS:84919849439

SN - 9780387255187

SN - 0387255176

SN - 9780387255170

SP - 85

EP - 108

BT - Experimental Models of Multiple Sclerosis

PB - Springer US

ER -