The role of cachectin/TNF in endotoxic shock and cachexia

Anthony Ceramil, Bruce Beutler

Research output: Contribution to journalReview article

233 Scopus citations


The histories of tumor necrosis factor (TNF) and cachectin have recently converged, with the recognition that they are one and the same molecule. Cachectin/TNF appears to be a major factor in the pathology that accompanies invasion by a foreign organism - the host mounts an exagerated response that is itself debilatory. Here, Bruce Beutler and Anthony Cerami review the involvement of cachectin/TNF in wasting and shock, as well as its more beneficial influences.

Original languageEnglish (US)
Pages (from-to)28-31
Number of pages4
JournalImmunology Today
Issue number1
StatePublished - 1988

ASJC Scopus subject areas

  • Immunology

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